Tbio URI1 Unconventional prefoldin RPB5 interactor 1

Protein Summary

Description

Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein. Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination. This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]

Uniprot Accession IDs

• O94763
• A8K805
• H7BY42
• Q8TC23
• Q9UNU3

Gene Name

• URI1

Ensembl ID

• ENST00000360605
• ENSP00000353817
• ENSG00000105176
• ENST00000392271
• ENSP00000376097

Symbol

• C19orf2
• NNX3
• PPP1R19
• RMP
• URI
• RMP
• URI
• NNX3
• C19orf2
• PPP1R19

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
kinase perturbation	0.95
biological process	0.84
cell type or tissue	0.77
molecular function	0.7

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Unconventional Prefoldin Rpb5 Interactor 1

DTO Classes

Protein / Transcription Factor / Unconventional Prefoldin Rpb5 Interactor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.69   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 201   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.69   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0