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Tbio
RECQL4
ATP-dependent DNA helicase Q4

Protein Summary
Description
DNA-dependent ATPase. May modulate chromosome segregation. The protein encoded by this gene is a DNA helicase that belongs to the RecQ helicase family. DNA helicases unwind double-stranded DNA into single-stranded DNAs and may modulate chromosome segregation. This gene is predominantly expressed in thymus and testis. Mutations in this gene are associated with Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000617875
  • ENSP00000482313
  • ENSG00000160957

Symbol
  • RECQ4
  • RECQ4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.92
phenotype
0.83
biological term
0.68
tissue sample
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.61   (req: < 5)
Gene RIFs: 69   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.61   (req: >= 5)
Gene RIFs: 69   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
1
8
94.2
mathematical ability
4
4
4
93.4
sex hormone-binding globulin measurement
6
2
6
90.7
self reported educational attainment
5
3
4
5.9
90.6
red blood cell distribution width
2
2
2
83
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
8
94.2
mathematical ability
4
93.4
sex hormone-binding globulin measurement
6
90.7
self reported educational attainment
4
5.9
90.6
red blood cell distribution width
2
83
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1931028
79456
Rat
RGD:1307732
300057
Horse
RecQ like helicase 4
VGNC:22287
100064627
Cow
RecQ like helicase 4
VGNC:33849
515472
Pig
RecQ like helicase 4
100524433
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
RecQ like helicase 4
Cow
RecQ like helicase 4
Pig
RecQ like helicase 4
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O94761-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (28)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
BHF-UCL
Protein-Protein Interactions (221)
1 – 10 of 221
SKAP1
Tbio
Family:  Enzyme
Novelty:  0.03753848
p_int:  0.997796652
p_ni:  0.002203348
Data Source:  BioPlex
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.997706108
p_ni:  0.00229389
p_wrong:  2e-9
Data Source:  BioPlex
KCTD17
Tbio
Novelty:  0.12105733
p_int:  0.957303196
p_ni:  0.042696528
p_wrong:  2.76e-7
Score:  0.167
Data Source:  BioPlex,STRINGDB
NLGN3
Tbio
Family:  Enzyme
Novelty:  0.00819625
p_int:  0.953498664
p_ni:  0.046501336
p_wrong:  1e-9
Score:  0.196
Data Source:  BioPlex,STRINGDB
NEUROG3
Tbio
Family:  TF
Novelty:  0.00341077
p_int:  0.924007685
p_ni:  0.075992313
p_wrong:  2e-9
Data Source:  BioPlex
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
p_int:  0.918984163
p_ni:  0.081015817
p_wrong:  2e-8
Score:  0.151
Data Source:  BioPlex,STRINGDB
RNH1
Tbio
Family:  Enzyme
Novelty:  0.00307468
p_int:  0.885201024
p_ni:  0.114798976
p_wrong:  1e-9
Data Source:  BioPlex
LZTS2
Tbio
Novelty:  0.09515452
p_int:  0.868328247
p_ni:  0.131671736
p_wrong:  1.7e-8
Score:  0.172
Data Source:  BioPlex,STRINGDB
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.853493117
p_ni:  0.146506883
Score:  0.19
Data Source:  BioPlex,STRINGDB
ARHGAP25
Tbio
Family:  Enzyme
Novelty:  0.14944305
p_int:  0.851514791
p_ni:  0.14848414
p_wrong:  0.000001068
Score:  0.169
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  190.61

PubMed score by year
PubTator Score  131.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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