DDAH1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Protein Summary
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq, Jul 2008]
- ENST00000284031
- ENSP00000284031
- ENSG00000153904
- ENST00000426972
- ENSP00000411189
- ENST00000535924
- ENSP00000439045
- DDAH
- DDAH
- DDAHI
- DDAH-1
- HEL-S-16
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
PubMedID | 0.93 | ||
transcription factor binding site profile | 0.86 | ||
gene perturbation | 0.77 | ||
microRNA | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 368.94 (req: < 5)
Gene RIFs: 68 (req: <= 3)
Antibodies: 263 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 368.94 (req: >= 5)
Gene RIFs: 68 (req: > 3)
Antibodies: 263 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0