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Tchem
DDAH1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

Protein Summary
Description
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284031
  • ENSP00000284031
  • ENSG00000153904
  • ENST00000426972
  • ENSP00000411189
  • ENST00000535924
  • ENSP00000439045

Symbol
  • DDAH
  • DDAH
  • DDAHI
  • DDAH-1
  • HEL-S-16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
PubMedID
0.93
transcription factor binding site profile
0.86
gene perturbation
0.77
microRNA
0.72


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 335.63   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 263   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 335.63   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (44)
DDAH2
Tbio
Family:  Enzyme
Novelty:  0.00355931
p_int:  0.999999687
p_ni:  3.12e-7
p_wrong:  1e-9
Score:  0.54
Data Source:  BioPlex,STRINGDB
FGB
Tbio
Novelty:  0.00437751
p_int:  0.862662373
p_ni:  0.137337625
p_wrong:  2e-9
Data Source:  BioPlex
FSD1
Tbio
Novelty:  0.03452477
p_int:  0.778038891
p_ni:  0.221961102
p_wrong:  7e-9
Score:  0.158
Data Source:  BioPlex,STRINGDB
AGXT2
Tbio
Family:  Enzyme
Novelty:  0.02018289
Score:  0.806
Data Source:  STRINGDB
NOS3
Tchem
Family:  Enzyme
Novelty:  0.00012407
Score:  0.731
Data Source:  STRINGDB
PRMT1
Tchem
Family:  Epigenetic
Novelty:  0.0032916
Score:  0.699
Data Source:  STRINGDB
B3GALT2
Tbio
Family:  Enzyme
Novelty:  0.23873109
Score:  0.666
Data Source:  STRINGDB
ZBTB12
Tbio
Family:  TF
Novelty:  0.15640131
Score:  0.663
Data Source:  STRINGDB
PCYT1B
Tbio
Family:  Enzyme
Novelty:  0.02972878
Score:  0.657
Data Source:  STRINGDB
LYPLA2
Tchem
Family:  Enzyme
Novelty:  0.05436006
Score:  0.653
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nitric oxide: eNOS activation and regulation
Reactome
eNOS activation
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nitric oxide: eNOS activation and regulation
eNOS activation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
3
0
1.2
91.1
asymmetrical dimethylarginine measurement
1
1
1
80.2
inflammatory biomarker measurement
1
2
0
35.6
65.5
appendicular lean mass
2
2
2
64.8
body height
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
91.1
asymmetrical dimethylarginine measurement
1
80.2
inflammatory biomarker measurement
0
35.6
65.5
appendicular lean mass
2
64.8
body height
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dimethylarginine dimethylaminohydrolase 1
VGNC:519
736613
Macaque
dimethylarginine dimethylaminohydrolase 1
711395
Mouse
MGI:1916469
69219
Rat
RGD:70968
64157
Dog
dimethylarginine dimethylaminohydrolase 1
VGNC:39827
490182
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dimethylarginine dimethylaminohydrolase 1
Macaque
dimethylarginine dimethylaminohydrolase 1
Mouse
Rat
Dog
dimethylarginine dimethylaminohydrolase 1
Publication Statistics
PubMed Score 335.63
PubMed score by year
PubTator Score 203.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title