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Tchem
TRPM2
Transient receptor potential cation channel subfamily M member 2

Protein Summary
Description
Isoform 1: Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels (PubMed:11960981, PubMed:12594222, PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:15561722, PubMed:16601673, PubMed:19171771, PubMed:20660597, PubMed:27383051, PubMed:27068538). Extracellular calcium passes through the channel and increases channel activity by binding to the cytoplasmic domain and stabilizing the channel in an open conformation (PubMed:19171771). Also contributes to Ca(2+) release from intracellular stores in response to ADP-ribose (PubMed:19454650). Plays a role in numerous processes that involve signaling via intracellular Ca(2+) levels (Probable). Besides, mediates the release of lysosomal Zn(2+) stores in response to reactive oxygen species, leading to increased cytosolic Zn(2+) levels (PubMed:25562606, PubMed:27068538). Activated by moderate heat (35 to 40 degrees Celsius) (PubMed:16601673). Activated by intra ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300481
  • ENSP00000300481
  • ENSG00000142185
  • ENST00000300482
  • ENSP00000300482
  • ENST00000397928
  • ENSP00000381023

Symbol
  • EREG1
  • KNP3
  • LTRPC2
  • TRPC7
  • KNP3
  • EREG1
  • TRPC7
  • LTRPC2
  • NUDT9H
  • LTrpC-2
  • NUDT9L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
biological term
0.75
disease perturbation
0.74
ligand (chemical)
0.63
gene perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.6   (req: < 5)
Gene RIFs: 95   (req: <= 3)
Antibodies: 265   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.6   (req: >= 5)
Gene RIFs: 95   (req: > 3)
Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (150)
CYBB
Tchem
Family:  IC
Novelty:  0.00054866
Score:  0.934
Data Source:  STRINGDB
TRPV2
Tchem
Family:  IC
Novelty:  0.00472952
Score:  0.928
Data Source:  STRINGDB
ATP8B4
Tbio
Family:  Transporter
Novelty:  0.19278107
Score:  0.924
Data Source:  STRINGDB
ITGB2
Tclin
Novelty:  0.00185859
Score:  0.924
Data Source:  STRINGDB
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
Score:  0.919
Data Source:  STRINGDB
KCNAB2
Tbio
Family:  IC
Novelty:  0.01752175
Score:  0.918
Data Source:  STRINGDB
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.918
Data Source:  STRINGDB
P2RX1
Tchem
Family:  IC
Novelty:  0.00286826
Score:  0.916
Data Source:  STRINGDB
MGAM
Tclin
Family:  Enzyme
Novelty:  0.00045865
Score:  0.916
Data Source:  STRINGDB
BST1
Tbio
Family:  Enzyme
Novelty:  0.01329061
Score:  0.916
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Ion channel transport
Reactome
Neutrophil degranulation
Reactome
Stimuli-sensing channels
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Ion channel transport
Neutrophil degranulation
Stimuli-sensing channels
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (34)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Addison disease
1
2
0
2.8
88.2
HbA1c measurement
1
3
3
67.4
1
1
0
4.2
63.7
balding measurement
1
1
1
62.5
2
1
0
1.6
61.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Addison disease
0
2.8
88.2
HbA1c measurement
3
67.4
0
4.2
63.7
balding measurement
1
62.5
0
1.6
61.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily M member 2
VGNC:7467
470101
Macaque
transient receptor potential cation channel subfamily M member 2
722161
Mouse
MGI:1351901
28240
Rat
RGD:1311889
294329
Dog
transient receptor potential cation channel subfamily M member 2
100855763
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily M member 2
Macaque
transient receptor potential cation channel subfamily M member 2
Mouse
Rat
Dog
transient receptor potential cation channel subfamily M member 2
Publication Statistics
PubMed Score 201.60
PubMed score by year
PubTator Score 226.49
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title