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Tchem
TRPM2
Transient receptor potential cation channel subfamily M member 2

Protein Summary
Description
Isoform 1: Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels (PubMed:11960981, PubMed:12594222, PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:15561722, PubMed:16601673, PubMed:19171771, PubMed:20660597, PubMed:27383051, PubMed:27068538). Extracellular calcium passes through the channel and increases channel activity by binding to the cytoplasmic domain and stabilizing the channel in an open conformation (PubMed:19171771). Also contributes to Ca(2+) release from intracellular stores in response to ADP-ribose (PubMed:19454650). Plays a role in numerous processes that involve signaling via intracellular Ca(2+) levels (Probable). Besides, mediates the release of lysosomal Zn(2+) stores in response to reactive oxygen species, leading to increased cytosolic Zn(2+) levels (PubMed:25562606, PubMed:27068538). Activated by moderate heat (35 to 40 degrees Celsius) (PubMed:16601673). Activated by intra ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300481
  • ENSP00000300481
  • ENSG00000142185
  • ENST00000300482
  • ENSP00000300482
  • ENST00000397928
  • ENSP00000381023

Symbol
  • EREG1
  • KNP3
  • LTRPC2
  • TRPC7
  • KNP3
  • EREG1
  • TRPC7
  • LTRPC2
  • NUDT9H
  • LTrpC-2
  • NUDT9L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
biological term
0.75
disease perturbation
0.74
ligand (chemical)
0.63
gene perturbation
0.61


Related Tools
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.41   (req: < 5)
Gene RIFs: 95   (req: <= 3)
Antibodies: 265   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.41   (req: >= 5)
Gene RIFs: 95   (req: > 3)
Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily M member 2
VGNC:7467
470101
Macaque
transient receptor potential cation channel subfamily M member 2
722161
Mouse
MGI:1351901
28240
Rat
RGD:1311889
294329
Dog
transient receptor potential cation channel subfamily M member 2
100855763
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily M member 2
Macaque
transient receptor potential cation channel subfamily M member 2
Mouse
Rat
Dog
transient receptor potential cation channel subfamily M member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O94759-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Ion channel transport
Reactome
Neutrophil degranulation
Reactome
Stimuli-sensing channels
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Ion channel transport
Neutrophil degranulation
Stimuli-sensing channels
Gene Ontology Terms (34)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (150)
1 – 10 of 150
CYBB
Tchem
Family: IC
Novelty: 0.00054866
Score: 0.934
Data Source: STRINGDB
TRPV2
Tchem
Family: IC
Novelty: 0.00472952
Score: 0.928
Data Source: STRINGDB
ATP8B4
Tdark
Family: Transporter
Novelty: 0.19278107
Score: 0.924
Data Source: STRINGDB
ITGB2
Tclin
Novelty: 0.00185859
Score: 0.924
Data Source: STRINGDB
C3AR1
Tchem
Family: GPCR
Novelty: 0.00527301
Score: 0.919
Data Source: STRINGDB
KCNAB2
Tbio
Family: IC
Novelty: 0.01752175
Score: 0.918
Data Source: STRINGDB
ITGAM
Tbio
Novelty: 0.00017521
Score: 0.918
Data Source: STRINGDB
P2RX1
Tchem
Family: IC
Novelty: 0.00286826
Score: 0.916
Data Source: STRINGDB
MGAM
Tclin
Family: Enzyme
Novelty: 0.00045865
Score: 0.916
Data Source: STRINGDB
BST1
Tbio
Family: Enzyme
Novelty: 0.01329061
Score: 0.916
Data Source: STRINGDB
Publication Statistics
PubMed Score  190.41

PubMed score by year
PubTator Score  226.49

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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