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Tbio
DXO
Decapping and exoribonuclease protein

Protein Summary
Description
Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity). This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The function of its protein product is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotes suggests that this may be a housekeeping gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337523
  • ENSP00000337759
  • ENSG00000204348
  • ENST00000375349
  • ENSP00000364498
  • ENST00000375356
  • ENSP00000364505
  • ENST00000383330
  • ENSP00000372820
  • ENSG00000206346
  • ENST00000399936
  • ENSP00000382818
  • ENST00000399937
  • ENSP00000382819
  • ENST00000414092
  • ENSP00000391123
  • ENSG00000236765
  • ENST00000419797
  • ENSP00000391532
  • ENSG00000234798
  • ENST00000426498
  • ENSP00000394167
  • ENSG00000225682
  • ENST00000427627
  • ENSP00000413860
  • ENST00000427690
  • ENSP00000406143
  • ENST00000432110
  • ENSP00000401315
  • ENST00000439989
  • ENSP00000395262
  • ENSG00000224313
  • ENST00000443250
  • ENSP00000415675
  • ENST00000446967
  • ENSP00000391349
  • ENST00000453742
  • ENSP00000410404
  • ENST00000454430
  • ENSP00000411380
  • ENST00000458308
  • ENSP00000400173

Symbol
  • DOM3L
  • DOM3Z
  • NG6
  • NG6
  • RAI1
  • DOM3L
  • DOM3Z
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
molecular function
0.84
transcription factor binding site profile
0.74
transcription factor
0.66
tissue sample
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.82   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.82   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (51)
1 – 10 of 51
RECQL5
Tbio
Family:  Enzyme
Novelty:  0.01558497
p_int:  0.999970173
p_ni:  0.000029811
p_wrong:  1.7e-8
Score:  0.825
Data Source:  BioPlex,STRINGDB
ARMC5
Tbio
Novelty:  0.02895521
p_int:  0.999258774
p_ni:  0.00009812
p_wrong:  0.000643106
Score:  0.547
Data Source:  BioPlex,STRINGDB
IGHA2
Tbio
p_int:  0.969466077
p_ni:  0.030532448
p_wrong:  0.000001475
Data Source:  BioPlex
POLR2M
Tbio
Family:  Enzyme
Novelty:  0.11413088
p_int:  0.91795852
p_ni:  0.081429371
p_wrong:  0.00061211
Score:  0.695
Data Source:  BioPlex,STRINGDB
RPAP2
Tbio
Family:  Enzyme
Novelty:  0.03383659
p_int:  0.884883393
p_ni:  0.115116607
Score:  0.725
Data Source:  BioPlex,STRINGDB
XRN2
Tbio
Family:  Enzyme
Novelty:  0.01478359
Score:  0.995
Data Source:  STRINGDB
XRN1
Tbio
Family:  Enzyme
Novelty:  0.00409381
Score:  0.948
Data Source:  STRINGDB
TJAP1
Tbio
Novelty:  0.008967
Score:  0.902
Data Source:  STRINGDB
EXOSC10
Tbio
Novelty:  0.00335571
Score:  0.862
Data Source:  STRINGDB
SKIV2L
Tbio
Family:  Enzyme
Novelty:  0.01108539
Score:  0.826
Data Source:  STRINGDB
Gene Ontology Terms (12)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (75)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
10
0
1.9
99.3
6
5
0
2.3
99
3
5
0
1.8
98.7
BMI-adjusted waist-hip ratio
5
20
25
98
atrophic macular degeneration
2
3
0
1.8
97.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.9
99.3
0
2.3
99
0
1.8
98.7
BMI-adjusted waist-hip ratio
25
98
atrophic macular degeneration
0
1.8
97.4
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
decapping exoribonuclease
716027
Mouse
MGI:1890444
112403
Rat
RGD:1303267
361799
Dog
decapping exoribonuclease
VGNC:40140
100855833
Horse
decapping exoribonuclease
VGNC:17364
100051343
Species
Name
OMA
EggNOG
Inparanoid
Macaque
decapping exoribonuclease
Mouse
Rat
Dog
decapping exoribonuclease
Horse
decapping exoribonuclease
Publication Statistics
PubMed Score 28.82
PubMed score by year
PubTator Score 4.88
PubTator score by year