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Tbio
CST7
Cystatin-F

Protein Summary
Description
Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. This gene encodes a glycosylated cysteine protease inhibitor with a putative role in immune regulation through inhibition of a unique target in the hematopoietic system. Expression of the protein has been observed in various human cancer cell lines established from malignant tumors. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000480798
  • ENSP00000420384
  • ENSG00000077984

Symbol
  • CMAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.74
tissue sample
0.59
disease
0.57
virus perturbation
0.55
cellular component
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.65   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.65   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
POTEE
Tbio
Novelty:  0.29349205
p_int:  0.999997829
p_ni:  0.000002168
p_wrong:  3e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
TUBA3C
Tchem
Novelty:  0.0187396
p_int:  0.996510478
p_ni:  0.003489522
Data Source:  BioPlex
ITIH3
Tbio
Novelty:  0.04201144
p_int:  0.995237679
p_ni:  0.004762315
p_wrong:  6e-9
Score:  0.274
Data Source:  BioPlex,STRINGDB
GALC
Tbio
Family:  Enzyme
Novelty:  0.00203532
p_int:  0.987738021
p_ni:  0.012261979
Score:  0.188
Data Source:  BioPlex,STRINGDB
CTSL
Tclin
Family:  Enzyme
Novelty:  0.00058727
p_int:  0.981553926
p_ni:  0.018446074
Score:  0.746
Data Source:  BioPlex,STRINGDB
TPT1
Tbio
Novelty:  0.00212091
p_int:  0.972608393
p_ni:  0.027380428
p_wrong:  0.000011178
Score:  0.309
Data Source:  BioPlex,STRINGDB
ATP2A3
Tchem
Family:  Transporter
Novelty:  0.0090982
p_int:  0.961863269
p_ni:  0.038136672
p_wrong:  5.9e-8
Score:  0.239
Data Source:  BioPlex,STRINGDB
STK32A
Tchem
Family:  Kinase
Novelty:  0.385805
p_int:  0.925700991
p_ni:  0.024589473
p_wrong:  0.049709536
Score:  0.54
Data Source:  BioPlex,STRINGDB
CTSC
Tchem
Family:  Enzyme
Novelty:  0.00119917
Score:  0.81
Data Source:  STRINGDB
CST9L
Tdark
Novelty:  0.21941207
Score:  0.768
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
3
1
3
42.3
C-reactive protein measurement
1
1
1
6.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
3
42.3
C-reactive protein measurement
1
6.1
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cystatin F
VGNC:13840
740962
Macaque
cystatin F
704850
Mouse
MGI:1298217
13011
Rat
RGD:1309154
296257
Dog
cystatin F
VGNC:39679
485563
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cystatin F
Macaque
cystatin F
Mouse
Rat
Dog
cystatin F
Publication Statistics
PubMed Score 32.65
PubMed score by year
PubTator Score 397.27
PubTator score by year
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Related Publications
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PMID
Year
Title