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Tbio
CST7
Cystatin-F

Protein Summary
Description
Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. This gene encodes a glycosylated cysteine protease inhibitor with a putative role in immune regulation through inhibition of a unique target in the hematopoietic system. Expression of the protein has been observed in various human cancer cell lines established from malignant tumors. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000480798
  • ENSP00000420384
  • ENSG00000077984

Symbol
  • CMAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.74
tissue sample
0.59
disease
0.57
virus perturbation
0.55
cellular component
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.57   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.57   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (65)
1 – 10 of 65
POTEE
Tbio
Novelty: 0.29349205
p_int: 0.999997829
p_ni: 0.000002168
p_wrong: 3e-9
Score: 0.177
Data Source: BioPlex,STRINGDB
TUBA3C
Tchem
Novelty: 0.0187396
p_int: 0.996510478
p_ni: 0.003489522
Data Source: BioPlex
ITIH3
Tbio
Novelty: 0.04201144
p_int: 0.995237679
p_ni: 0.004762315
p_wrong: 6e-9
Score: 0.274
Data Source: BioPlex,STRINGDB
GALC
Tbio
Family: Enzyme
Novelty: 0.00203532
p_int: 0.987738021
p_ni: 0.012261979
Score: 0.188
Data Source: BioPlex,STRINGDB
CTSL
Tclin
Family: Enzyme
Novelty: 0.00058727
p_int: 0.981553926
p_ni: 0.018446074
Score: 0.746
Data Source: BioPlex,STRINGDB
TPT1
Tbio
Novelty: 0.00212091
p_int: 0.972608393
p_ni: 0.027380428
p_wrong: 0.000011178
Score: 0.309
Data Source: BioPlex,STRINGDB
ATP2A3
Tbio
Family: Transporter
Novelty: 0.0090982
p_int: 0.961863269
p_ni: 0.038136672
p_wrong: 5.9e-8
Score: 0.239
Data Source: BioPlex,STRINGDB
STK32A
Tchem
Family: Kinase
Novelty: 0.385805
p_int: 0.925700991
p_ni: 0.024589473
p_wrong: 0.049709536
Score: 0.54
Data Source: BioPlex,STRINGDB
CTSC
Tchem
Family: Enzyme
Novelty: 0.00119917
Score: 0.81
Data Source: STRINGDB
CST9L
Tdark
Novelty: 0.21941207
Score: 0.768
Data Source: STRINGDB
Publication Statistics
PubMed Score  29.57

PubMed score by year
PubTator Score  397.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer