Protein Summary
Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. This gene encodes a glycosylated cysteine protease inhibitor with a putative role in immune regulation through inhibition of a unique target in the hematopoietic system. Expression of the protein has been observed in various human cancer cell lines established from malignant tumors. [provided by RefSeq, Jul 2008]
- ENST00000480798
- ENSP00000420384
- ENSG00000077984
- CMAP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.74 | ||
tissue sample | 0.59 | ||
disease | 0.57 | ||
virus perturbation | 0.55 | ||
cellular component | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.65 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 158 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.65 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 158 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (65)
POTEE
Novelty: 0.29349205
p_int: 0.999997829
p_ni: 0.000002168
p_wrong: 3e-9
Score: 0.177
Data Source: BioPlex,STRINGDB
ITIH3
Novelty: 0.04201144
p_int: 0.995237679
p_ni: 0.004762315
p_wrong: 6e-9
Score: 0.274
Data Source: BioPlex,STRINGDB
GALC
Family: Enzyme
Novelty: 0.00203532
p_int: 0.987738021
p_ni: 0.012261979
Score: 0.188
Data Source: BioPlex,STRINGDB
CTSL
Family: Enzyme
Novelty: 0.00058727
p_int: 0.981553926
p_ni: 0.018446074
Score: 0.746
Data Source: BioPlex,STRINGDB
TPT1
Novelty: 0.00212091
p_int: 0.972608393
p_ni: 0.027380428
p_wrong: 0.000011178
Score: 0.309
Data Source: BioPlex,STRINGDB
ATP2A3
Family: Transporter
Novelty: 0.0090982
p_int: 0.961863269
p_ni: 0.038136672
p_wrong: 5.9e-8
Score: 0.239
Data Source: BioPlex,STRINGDB
STK32A
Family: Kinase
Novelty: 0.385805
p_int: 0.925700991
p_ni: 0.024589473
p_wrong: 0.049709536
Score: 0.54
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (5)
Functions (2)
Components (2)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
alcohol consumption measurement | 3 | 1 | 3 | 42.3 | |||||
C-reactive protein measurement | 1 | 1 | 1 | 6.1 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
alcohol consumption measurement | 3 | 42.3 | |||||
C-reactive protein measurement | 1 | 6.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cystatin F | VGNC:13840 | 740962 | |||||
Macaque | cystatin F | 704850 | ||||||
Mouse | MGI:1298217 | 13011 | ||||||
Rat | RGD:1309154 | 296257 | ||||||
Dog | cystatin F | VGNC:39679 | 485563 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cystatin F | |||||
Macaque | cystatin F | |||||
Mouse | ||||||
Rat | ||||||
Dog | cystatin F | |||||
Publication Statistics
PubMed Score 32.65
PubMed score by year
PubTator Score 397.27
PubTator score by year
Related Publications
Text Mined References (21)
GeneRif Annotations (9)
Items per page:
0 of 0
PMID | Year | Title |
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