Protein Summary
Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).
- ENST00000271843
- ENSP00000271843
- ENSG00000143543
- ENST00000356648
- ENSP00000349069
- ENST00000368589
- ENSP00000357578
- ENST00000428469
- ENSP00000395250
- PAR
- hJT
- HJTB
- HSPC222
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
co-expressed gene | 0.99 | ||
kinase perturbation | 0.91 | ||
virus perturbation | 0.83 | ||
tissue | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 25.45 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 98 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 25.45 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 98 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0