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Tbio
SRP72
Signal recognition particle subunit SRP72

Protein Summary
Description
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function. This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of secretory proteins to the endoplasmic reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein subunits: SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72, that are bound to the 7S RNA as monomers or heterodimers. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein. Mutations in this gene are associated with familial bone marrow failure. Alternatively spliced transcript varia ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342756
  • ENSP00000342181
  • ENSG00000174780
  • ENST00000510663
  • ENSP00000424576
  • ENST00000642900
  • ENSP00000495128

Symbol
  • BMFF
  • BMFS1
  • HEL103
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
drug perturbation
0.99
interacting protein
0.99
disease perturbation
0.93
transcription factor perturbation
0.91


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.78   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.78   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
signal recognition particle 72
694604
Mouse
MGI:1333795
66661
Dog
signal recognition particle 72
VGNC:46809
403944
Horse
signal recognition particle 72
VGNC:23589
100053755
Cow
signal recognition particle 72
VGNC:35287
509430
Species
Name
OMA
EggNOG
Inparanoid
Macaque
signal recognition particle 72
Mouse
Dog
signal recognition particle 72
Horse
signal recognition particle 72
Cow
signal recognition particle 72
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O76094-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
SRP-dependent cotranslational protein targeting to membrane
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
SRP-dependent cotranslational protein targeting to membrane
Translation
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (163)
1 – 10 of 163
SRP68
Tbio
Novelty: 0.04666697
p_int: 0.999987647
p_ni: 0.000012353
Score: 0.999
Data Source: BioPlex,STRINGDB
SRP9
Tbio
Novelty: 0.02243103
p_int: 0.999976389
p_ni: 0.000023611
Score: 0.999
Data Source: BioPlex,STRINGDB
WDR46
Tbio
Novelty: 0.19307408
p_int: 0.788741447
p_ni: 0.211258553
Score: 0.181
Data Source: BioPlex,STRINGDB
SRP19
Tbio
Novelty: 0.01831843
Score: 0.999
Data Source: STRINGDB
SRP14
Tbio
Novelty: 0.03745351
Score: 0.999
Data Source: STRINGDB
SRP54
Tbio
Novelty: 0.00535567
Score: 0.999
Data Source: STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.981
Data Source: STRINGDB
SRPRA
Tbio
Novelty: 0.01248718
Score: 0.98
Data Source: STRINGDB
RPL23
Tbio
Novelty: 0.02741113
Score: 0.976
Data Source: STRINGDB
RPL9
Tbio
Novelty: 0.00845583
Score: 0.975
Data Source: STRINGDB
Publication Statistics
PubMed Score  29.78

PubMed score by year
PubTator Score  25.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer