Tchem PDE9A High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Protein Summary

Description

Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755, PubMed:21483814). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity). The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O76083
• B2RBI5
• B4DFI5
• D3DSJ8
• D3DSJ9
• O75490
• O75491
• O95225
• Q53Y40
• Q5QD39
• Q86SF7
• Q86SI6
• Q86SJ3
• Q86WN3
• Q86WN4
• Q86WN5
• Q86WN6
• Q86WN7
• Q86WN8
• Q86WN9
• Q86WP0

Gene Name

• PDE9A

Ensembl ID

• ENST00000291539
• ENSP00000291539
• ENSG00000160191
• ENST00000328862
• ENSP00000328699
• ENST00000335440
• ENSP00000335365
• ENST00000335512
• ENSP00000335242
• ENST00000349112
• ENSP00000344730
• ENST00000380328
• ENSP00000369685
• ENST00000398224
• ENSP00000381280
• ENST00000398225
• ENSP00000381281
• ENST00000398227
• ENSP00000381283
• ENST00000398229
• ENSP00000381285
• ENST00000398232
• ENSP00000381287
• ENST00000398234
• ENSP00000381289
• ENST00000398236
• ENSP00000381291

Symbol

• HSPDE9A2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.76
PubMedID	0.73
disease	0.63
transcription factor binding site profile	0.59
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.93   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 207   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.93   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 443

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1