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Tchem
PDE9A
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Protein Summary
Description
Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755, PubMed:21483814). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity). The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291539
  • ENSP00000291539
  • ENSG00000160191
  • ENST00000328862
  • ENSP00000328699
  • ENST00000335440
  • ENSP00000335365
  • ENST00000335512
  • ENSP00000335242
  • ENST00000349112
  • ENSP00000344730
  • ENST00000380328
  • ENSP00000369685
  • ENST00000398224
  • ENSP00000381280
  • ENST00000398225
  • ENSP00000381281
  • ENST00000398227
  • ENSP00000381283
  • ENST00000398229
  • ENSP00000381285
  • ENST00000398232
  • ENSP00000381287
  • ENST00000398234
  • ENSP00000381289
  • ENST00000398236
  • ENSP00000381291

Symbol
  • HSPDE9A2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.76
PubMedID
0.73
disease
0.63
transcription factor binding site profile
0.59
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.11   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.11   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 443
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
vardenafil
Rendered image for vardenafil
Active Ligands (443)
1 – 10 of 443
SCH51866
Rendered image for SCH51866
(+)-Cyclomorusin
Rendered image for (+)-Cyclomorusin
zaprinast
Rendered image for zaprinast
CHEMBL3360415
Rendered image for CHEMBL3360415
CHEMBL583914
Rendered image for CHEMBL583914
CHEMBL466474
Rendered image for CHEMBL466474
CHEMBL3360412
Rendered image for CHEMBL3360412
CHEMBL466280
Rendered image for CHEMBL466280
CHEMBL3360416
Rendered image for CHEMBL3360416
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
77.8
hemoglobin measurement
2
2
2
73.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
77.8
hemoglobin measurement
2
73.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 9A
VGNC:1134
474020
Macaque
phosphodiesterase 9A
100301991
Mouse
MGI:1277179
18585
Rat
RGD:621035
191569
Dog
phosphodiesterase 9A
VGNC:44367
611022
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 9A
Macaque
phosphodiesterase 9A
Mouse
Rat
Dog
phosphodiesterase 9A
Protein Structure (21 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O76083-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 21
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Nitric oxide stimulates guanylate cyclase
Reactome
Platelet homeostasis
Reactome
cGMP effects
Name
Explore in Pharos
Explore in Source
Hemostasis
Nitric oxide stimulates guanylate cyclase
Platelet homeostasis
cGMP effects
Protein-Protein Interactions (77)
1 – 10 of 77
UNC119
Tchem
Novelty:  0.00396292
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.329
Data Source:  BioPlex,STRINGDB
GUCY1A2
Tclin
Family:  Enzyme
Novelty:  0.05335767
Score:  0.813
Data Source:  STRINGDB
GUCY1B1
Tclin
Family:  Enzyme
Novelty:  0.03618378
Score:  0.798
Data Source:  STRINGDB
GUCY1A1
Tclin
Family:  Enzyme
Novelty:  0.02289791
Score:  0.787
Data Source:  STRINGDB
ADCY10
Tchem
Family:  Enzyme
Novelty:  0.00037654
Score:  0.784
Data Source:  STRINGDB
NPR1
Tclin
Family:  Kinase
Novelty:  0.00170829
Score:  0.753
Data Source:  STRINGDB
ADCY5
Tchem
Family:  Enzyme
Novelty:  0.00307839
Score:  0.752
Data Source:  STRINGDB
NPR2
Tbio
Family:  Kinase
Novelty:  0.00418989
Score:  0.752
Data Source:  STRINGDB
GUCY2D
Tbio
Family:  Kinase
Novelty:  0.00578343
Score:  0.751
Data Source:  STRINGDB
GUCY2F
Tbio
Family:  Kinase
Novelty:  0.03634576
Score:  0.747
Data Source:  STRINGDB
Publication Statistics
PubMed Score  61.11

PubMed score by year
PubTator Score  32.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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