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Tbio
RGS20
Regulator of G-protein signaling 20

Protein Summary
Description
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding diffe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276500
  • ENSP00000276500
  • ENSG00000147509
  • ENST00000297313
  • ENSP00000297313
  • ENST00000344277
  • ENSP00000344630

Symbol
  • RGSZ1
  • ZGAP1
  • RGSZ1
  • ZGAP1
  • gz-GAP
  • g(z)GAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.77
virus perturbation
0.72
tissue sample
0.6
gene perturbation
0.59
transcription factor
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.64   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.64   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
AARSD1
Tdark
Novelty:  0.75372406
p_int:  0.999999954
p_ni:  4.6e-8
Data Source:  BioPlex
TTC7B
Tbio
Novelty:  0.22257455
p_int:  0.999999695
p_ni:  3.05e-7
Score:  0.211
Data Source:  BioPlex,STRINGDB
NARF
Tbio
Novelty:  0.06990726
p_int:  0.999999657
p_ni:  3.2e-7
p_wrong:  2.3e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
CRY1
Tchem
Novelty:  0.00116593
p_int:  0.999998002
p_ni:  0.000001997
p_wrong:  1e-9
Score:  0.182
Data Source:  BioPlex,STRINGDB
SELENOO
Tdark
Novelty:  0.02959704
p_int:  0.999994591
p_ni:  0.000005399
p_wrong:  1e-8
Data Source:  BioPlex
GLRX3
Tbio
Novelty:  0.0096265
p_int:  0.999993154
p_ni:  0.000006846
Score:  0.445
Data Source:  BioPlex,STRINGDB
EFR3B
Tbio
Novelty:  0.61495463
p_int:  0.999990898
p_ni:  0.000009066
p_wrong:  3.6e-8
Data Source:  BioPlex
FAM126A
Tbio
Novelty:  0.0250547
p_int:  0.999986272
p_ni:  0.000013725
p_wrong:  3e-9
Data Source:  BioPlex
NBN
Tbio
Novelty:  0.00759456
p_int:  0.99995272
p_ni:  0.00004725
p_wrong:  3e-8
Score:  0.156
Data Source:  BioPlex,STRINGDB
RAD50
Tbio
Novelty:  0.02161298
p_int:  0.999902666
p_ni:  0.000097334
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
G alpha (z) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
G alpha (z) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regulator of G protein signaling 20
VGNC:3005
740330
Macaque
regulator of G protein signaling 20
693454
Mouse
MGI:1929866
58175
Rat
RGD:1586146
362477
Dog
regulator of G protein signaling 20
VGNC:45530
486954
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regulator of G protein signaling 20
Macaque
regulator of G protein signaling 20
Mouse
Rat
Dog
regulator of G protein signaling 20
Publication Statistics
PubMed Score 25.64
PubMed score by year
PubTator Score 12.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title