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Tbio
WISP2
WNT1-inducible-signaling pathway protein 2

Protein Summary
Description
May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production. This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expres ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000190983
  • ENSP00000190983
  • ENSG00000064205
  • ENST00000372865
  • ENSP00000361956
  • ENST00000372868
  • ENSP00000361959

Symbol
  • CCN5
  • CT58
  • CTGFL
  • CT58
  • WISP2
  • CTGF-L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.93
protein domain
0.73
disease perturbation
0.68
cell type or tissue
0.65
molecular function
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.55   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 293   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.55   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 293   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adenosine deaminase measurement
1
1
0
1.1
80.2
diet measurement
1
1
1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adenosine deaminase measurement
0
1.1
80.2
diet measurement
1
26.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WNT1 inducible signaling pathway protein 2
VGNC:6308
458271
Mouse
MGI:1328326
22403
Rat
RGD:621867
29576
Dog
WNT1 inducible signaling pathway protein 2
VGNC:48415
610928
Horse
WNT1 inducible signaling pathway protein 2
VGNC:25038
100070779
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WNT1 inducible signaling pathway protein 2
Mouse
Rat
Dog
WNT1 inducible signaling pathway protein 2
Horse
WNT1 inducible signaling pathway protein 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O76076-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (21)
1 – 10 of 21
ICAM1
Tchem
Novelty:  0.00009746
p_int:  0.977258835
p_ni:  0.018934258
p_wrong:  0.003806907
Score:  0.225
Data Source:  BioPlex,STRINGDB
TRIM68
Tbio
Family:  Enzyme
Novelty:  0.11729189
p_int:  0.954353186
p_ni:  0.045646814
Score:  0.228
Data Source:  BioPlex,STRINGDB
ZNF423
Tbio
Family:  TF
Novelty:  0.01718703
Score:  0.683
Data Source:  STRINGDB
SNX9
Tbio
Novelty:  0.01737783
Score:  0.628
Data Source:  STRINGDB
WNT1
Tbio
Novelty:  0.00124301
Score:  0.593
Data Source:  STRINGDB
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.593
Data Source:  STRINGDB
LEP
Tbio
Novelty:  0.00005295
Score:  0.584
Data Source:  STRINGDB
BMP4
Tchem
Novelty:  0.00047387
Score:  0.571
Data Source:  STRINGDB
CCNL2
Tbio
Novelty:  0.03667817
Score:  0.559
Data Source:  STRINGDB
IGF1
Tbio
Novelty:  0.00003878
Score:  0.542
Data Source:  STRINGDB
Publication Statistics
PubMed Score  95.55

PubMed score by year
PubTator Score  51.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer