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Tbio
DFFB
DNA fragmentation factor subunit beta

Protein Summary
Description
Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology. Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined. [p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339350
  • ENSP00000343218
  • ENSG00000169598
  • ENST00000378209
  • ENSP00000367454
  • ENST00000491998
  • ENSP00000436775

Symbol
  • CAD
  • DFF2
  • DFF40
  • CAD
  • CPAN
  • DFF2
  • DFF40
  • DFF-40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
kinase perturbation
0.84
transcription factor binding site profile
0.69
cellular component
0.68
small molecule perturbation
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.73   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 471   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.73   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 471   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (76)
1 – 10 of 76
DFFA
Tbio
Novelty:  0.00253065
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
MAGOH
Tbio
Novelty:  0.03637008
p_int:  0.999956925
p_ni:  0.000035481
p_wrong:  0.000007594
Score:  0.719
Data Source:  BioPlex,STRINGDB
PTPN13
Tchem
Family:  Enzyme
Novelty:  0.00434963
p_int:  0.999946545
p_ni:  0.000053431
p_wrong:  2.4e-8
Score:  0.252
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.99426909
p_ni:  0.00573091
Data Source:  BioPlex
LRRC15
Tbio
Novelty:  0.03701624
p_int:  0.963168894
p_ni:  0.036831106
Data Source:  BioPlex
PKN2
Tchem
Family:  Kinase
Novelty:  0.0088412
p_int:  0.947880762
p_ni:  0.052119237
p_wrong:  1e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
PRKACB
Tchem
Family:  Kinase
Novelty:  0.01962222
p_int:  0.900421942
p_ni:  0.099578058
Score:  0.224
Data Source:  BioPlex,STRINGDB
NEFH
Tbio
Novelty:  0.0013027
p_int:  0.775809044
p_ni:  0.224190794
p_wrong:  1.62e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
CASP3
Tchem
Family:  Enzyme
Novelty:  0.00003555
Score:  0.979
Data Source:  Reactome,STRINGDB
H1F0
Tchem
Novelty:  0.00039686
Score:  0.951
Data Source:  Reactome,STRINGDB
Pathways (11)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptosis induced DNA fragmentation
Reactome
Apoptotic execution phase
Reactome
Programmed Cell Death
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptosis induced DNA fragmentation
Apoptotic execution phase
Programmed Cell Death
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
3
7
96.6
reticulocyte count
7
2
9
94.7
reticulocyte measurement
3
2
5
94.3
hemoglobin measurement
3
2
3
91.9
mean corpuscular volume
1
1
1
86.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
7
96.6
reticulocyte count
9
94.7
reticulocyte measurement
5
94.3
hemoglobin measurement
3
91.9
mean corpuscular volume
1
86.7
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA fragmentation factor subunit beta
VGNC:10600
744932
Macaque
DNA fragmentation factor subunit beta
722487
Mouse
MGI:1196287
13368
Rat
RGD:620335
84359
Dog
DNA fragmentation factor subunit beta
VGNC:39910
489623
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA fragmentation factor subunit beta
Macaque
DNA fragmentation factor subunit beta
Mouse
Rat
Dog
DNA fragmentation factor subunit beta
Publication Statistics
PubMed Score 168.73
PubMed score by year
PubTator Score 155.43
PubTator score by year