Tbio DFFB DNA fragmentation factor subunit beta

Protein Summary

Description

Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology. Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined. [provided by RefSeq, Sep 2013]

Uniprot Accession IDs

• O76075
• O60521
• Q5SR22
• Q9BYI4
• Q9BYI5
• Q9BYI6

Gene Name

• DFFB

Ensembl ID

• ENST00000339350
• ENSP00000343218
• ENSG00000169598
• ENST00000378209
• ENSP00000367454
• ENST00000491998
• ENSP00000436775

Symbol

• CAD
• DFF2
• DFF40
• CAD
• CPAN
• DFF2
• DFF40
• DFF-40

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
kinase perturbation	0.84
transcription factor binding site profile	0.69
cellular component	0.68
small molecule perturbation	0.57

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Dna Fragmentation Factor Subunit Beta

DTO Classes

Protein / Enzyme / Nuclease / Dna Fragmentation Factor Subunit Beta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.39   (req: < 5)

Gene RIFs: 42   (req: <= 3)

Antibodies: 471   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.39   (req: >= 5)

Gene RIFs: 42   (req: > 3)

Antibodies: 471   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0