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Tclin
PDE5A
cGMP-specific 3',5'-cyclic phosphodiesterase

Protein Summary
Description
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:9714779, PubMed:15489334). Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334). This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264805
  • ENSP00000264805
  • ENSG00000138735
  • ENST00000354960
  • ENSP00000347046

Symbol
  • PDE5
  • CN5A
  • PDE5
  • CGB-PDE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
gene perturbation
0.92
molecular function
0.88
transcription factor perturbation
0.88
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3317.93   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3317.93   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1169
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 9
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
59
monocyte count
1
1
1
53.6
BMI-adjusted waist-hip ratio
4
1
4
31.6
appendicular lean mass
1
1
1
26.2
platelet crit
1
1
1
19.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
59
monocyte count
1
53.6
BMI-adjusted waist-hip ratio
4
31.6
appendicular lean mass
1
26.2
platelet crit
1
19.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 5A
VGNC:2966
461461
Macaque
phosphodiesterase 5A
705592
Mouse
MGI:2651499
242202
Rat
RGD:620995
171115
Dog
phosphodiesterase 5A
VGNC:44356
403825
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 5A
Macaque
phosphodiesterase 5A
Mouse
Rat
Dog
phosphodiesterase 5A
Protein Structure (37 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O76074-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 37
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (58)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Nitric oxide stimulates guanylate cyclase
Reactome
Platelet homeostasis
Reactome
cGMP effects
Name
Explore in Pharos
Explore in Source
Hemostasis
Nitric oxide stimulates guanylate cyclase
Platelet homeostasis
cGMP effects
Protein-Protein Interactions (127)
1 – 10 of 127
PDE6G
Tclin
Family: Enzyme
Novelty: 0.03113994
Score: 0.961
Data Source: STRINGDB
PRKG1
Tchem
Family: Kinase
Novelty: 0.0014943
Score: 0.931
Data Source: STRINGDB
ALDH7A1
Tbio
Family: Enzyme
Novelty: 0.00069494
Score: 0.921
Data Source: STRINGDB
NPR1
Tclin
Family: Kinase
Novelty: 0.00170829
Score: 0.901
Data Source: STRINGDB
GUCY2C
Tclin
Family: Kinase
Novelty: 0.00209733
Score: 0.895
Data Source: STRINGDB
PDE2A
Tclin
Family: Enzyme
Novelty: 0.00862513
Score: 0.864
Data Source: STRINGDB
NPR2
Tbio
Family: Kinase
Novelty: 0.00418989
Score: 0.857
Data Source: STRINGDB
GUCY2F
Tbio
Family: Kinase
Novelty: 0.03634576
Score: 0.854
Data Source: STRINGDB
GUCY1B1
Tclin
Family: Enzyme
Novelty: 0.03618378
Score: 0.845
Data Source: STRINGDB
GUCY1A1
Tclin
Family: Enzyme
Novelty: 0.02289791
Score: 0.831
Data Source: STRINGDB
Publication Statistics
PubMed Score  3317.93

PubMed score by year
PubTator Score  1867.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer