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Tbio
SNCG
Gamma-synuclein

Protein Summary
Description
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372017
  • ENSP00000361087
  • ENSG00000173267

Symbol
  • BCSG1
  • PERSYN
  • PRSN
  • SR
  • BCSG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.72
PubMedID
0.7
disease perturbation
0.68
gene perturbation
0.68
cellular component
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.69   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 401   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.69   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 401   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
SULT1A1
Tchem
Family:  Enzyme
Novelty:  0.00238409
Score:  0.821
Data Source:  STRINGDB
UBA2
Tbio
Novelty:  0.01582807
Score:  0.82
Data Source:  STRINGDB
BUB1B
Tbio
Family:  Kinase
Novelty:  0.00239073
Score:  0.783
Data Source:  STRINGDB
PFDN2
Tbio
Novelty:  0.08537716
Score:  0.643
Data Source:  STRINGDB
SYNC
Tbio
Novelty:  0.04605223
Score:  0.625
Data Source:  STRINGDB
SSSCA1
Tdark
Novelty:  0.53523038
Score:  0.603
Data Source:  STRINGDB
MYOC
Tchem
Novelty:  0.00138004
Score:  0.571
Data Source:  STRINGDB
ATOH7
Tbio
Family:  TF
Novelty:  0.00536814
Score:  0.558
Data Source:  STRINGDB
METTL14
Tbio
Family:  Enzyme
Novelty:  0.01377112
Score:  0.552
Data Source:  STRINGDB
SLC23A1
Tchem
Family:  Transporter
Novelty:  0.01118389
Score:  0.526
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
56.6
leukocyte count
1
1
1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
56.6
leukocyte count
1
27.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
synuclein gamma
VGNC:5787
450574
Macaque
synuclein gamma
696535
Mouse
MGI:1298397
20618
Rat
RGD:70996
64347
Dog
synuclein gamma
VGNC:46599
611053
Species
Name
OMA
EggNOG
Inparanoid
Chimp
synuclein gamma
Macaque
synuclein gamma
Mouse
Rat
Dog
synuclein gamma
Publication Statistics
PubMed Score 247.69
PubMed score by year
PubTator Score 152.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title