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Tbio
RNF8
E3 ubiquitin-protein ligase RNF8

Protein Summary
Description
E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dep ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229866
  • ENSP00000229866
  • ENSG00000112130
  • ENST00000373479
  • ENSP00000362578
  • ENST00000469731
  • ENSP00000418879

Symbol
  • KIAA0646
  • hRNF8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
biological process
0.95
virus perturbation
0.92
protein domain
0.85
microRNA
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.17   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 309   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.17   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 309   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (172)
RNF168
Tbio
Family:  Enzyme
Novelty:  0.01827754
Score:  0.993
Data Source:  Reactome,STRINGDB
MDC1
Tbio
Novelty:  0.00533097
Score:  0.991
Data Source:  Reactome,STRINGDB
TP53BP1
Tbio
Family:  Epigenetic
Novelty:  0.00131256
Score:  0.99
Data Source:  Reactome,STRINGDB
UBE2N
Tchem
Novelty:  0.00620946
Score:  0.986
Data Source:  Reactome,STRINGDB
BRCA1
Tchem
Novelty:  0.00011146
Score:  0.986
Data Source:  STRINGDB
UIMC1
Tbio
Novelty:  0.02039732
Score:  0.985
Data Source:  Reactome,STRINGDB
ATM
Tchem
Family:  Kinase
Novelty:  0.00019169
Score:  0.985
Data Source:  Reactome,STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
Score:  0.984
Data Source:  Reactome,STRINGDB
BARD1
Tbio
Novelty:  0.00513841
Score:  0.978
Data Source:  STRINGDB
UBE2V2
Tbio
Novelty:  0.01112479
Score:  0.973
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (98)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
DNA Double Strand Break Response
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
DNA Double Strand Break Response
DNA Double-Strand Break Repair
DNA Repair
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (35)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
42.1
platelet crit
2
1
2
7.5
apolipoprotein A 1 measurement
1
1
1
1.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
42.1
platelet crit
2
7.5
apolipoprotein A 1 measurement
1
1.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ring finger protein 8
100424611
Mouse
MGI:1929069
58230
Rat
RGD:1308035
361815
Dog
ring finger protein 8
VGNC:45676
481775
Horse
ring finger protein 8
VGNC:22487
100053995
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ring finger protein 8
Mouse
Rat
Dog
ring finger protein 8
Horse
ring finger protein 8
Publication Statistics
PubMed Score 107.17
PubMed score by year
PubTator Score 70.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title