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Tbio
TM7SF2
Delta(14)-sterol reductase

Protein Summary
Description
Involved in the conversion of lanosterol to cholesterol.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279263
  • ENSP00000279263
  • ENSG00000149809
  • ENST00000345348
  • ENSP00000329520

Symbol
  • ANG1
  • ANG1
  • C14SR
  • NET47
  • DHCR14A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
transcription factor perturbation
0.88
virus perturbation
0.79
transcription factor binding site profile
0.78
cellular component
0.75


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.29   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.29   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane 7 superfamily member 2
VGNC:985
451314
Macaque
transmembrane 7 superfamily member 2
721985
Mouse
MGI:1920416
73166
Rat
RGD:1311205
293688
Dog
transmembrane 7 superfamily member 2
VGNC:47413
476027
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane 7 superfamily member 2
Macaque
transmembrane 7 superfamily member 2
Mouse
Rat
Dog
transmembrane 7 superfamily member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O76062-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
Cholesterol biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
Cholesterol biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroids
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (78)
1 – 10 of 78
CYP51A1
Tchem
Family: Enzyme
Novelty: 0.00127373
Score: 0.99
Data Source: STRINGDB
MSMO1
Tbio
Family: Enzyme
Novelty: 0.01263528
Score: 0.985
Data Source: STRINGDB
EBP
Tchem
Family: Enzyme
Novelty: 0.00610658
Score: 0.972
Data Source: STRINGDB
DHCR24
Tbio
Family: Enzyme
Novelty: 0.00480473
Score: 0.972
Data Source: STRINGDB
SREBF2
Tchem
Family: TF
Novelty: 0.00171709
Score: 0.94
Data Source: STRINGDB
SC5D
Tbio
Family: Enzyme
Novelty: 0.02446366
Score: 0.923
Data Source: STRINGDB
NSDHL
Tbio
Family: Enzyme
Novelty: 0.01651408
Score: 0.912
Data Source: STRINGDB
NFYC
Tbio
Family: TF
Novelty: 0.00626931
Score: 0.904
Data Source: STRINGDB
NFYB
Tbio
Family: TF
Novelty: 0.00419747
Score: 0.902
Data Source: STRINGDB
NFYA
Tbio
Family: TF
Novelty: 0.00507094
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.29

PubMed score by year
PubTator Score  13.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer