Tbio STC2 Stanniocalcin-2

Protein Summary

Description

Has an anti-hypocalcemic action on calcium and phosphate homeostasis. This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O76061
• STC-2

Gene Name

• STC2

Ensembl ID

• ENST00000265087
• ENSP00000265087
• ENSG00000113739

Symbol

• STC-2
• STCRP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.99
small molecule perturbation	0.96
gene perturbation	0.95
transcription factor binding site profile	0.91
transcription factor perturbation	0.8

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Peptide Hormone / Stanniocalcin-2

DTO Classes

Protein / Signaling / Hormone / Stanniocalcin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.55   (req: < 5)

Gene RIFs: 77   (req: <= 3)

Antibodies: 379   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.55   (req: >= 5)

Gene RIFs: 77   (req: > 3)

Antibodies: 379   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0