Protein Summary
Has an anti-hypocalcemic action on calcium and phosphate homeostasis. This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq, Jul 2008]
- ENST00000265087
- ENSP00000265087
- ENSG00000113739
- STC-2
- STCRP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.99 | ||
small molecule perturbation | 0.96 | ||
gene perturbation | 0.95 | ||
transcription factor binding site profile | 0.91 | ||
transcription factor perturbation | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 136.28 (req: < 5)
Gene RIFs: 45 (req: <= 3)
Antibodies: 379 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 136.28 (req: >= 5)
Gene RIFs: 45 (req: > 3)
Antibodies: 379 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (147)
LY86
Novelty: 0.00314575
p_int: 0.902738453
p_ni: 0.097260796
p_wrong: 7.52e-7
Data Source: BioPlex
CCNJL
Novelty: 2.86306774
p_int: 0.873216427
p_ni: 0.126783573
Score: 0.453
Data Source: BioPlex,STRINGDB
CRP
Novelty: 0.00001517
p_int: 0.867209221
p_ni: 0.132786082
p_wrong: 0.000004698
Score: 0.187
Data Source: BioPlex,STRINGDB
MMP19
Family: Enzyme
Novelty: 0.01407961
p_int: 0.754290361
p_ni: 0.245706624
p_wrong: 0.000003016
Data Source: BioPlex
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Reactome | Post-translational protein phosphorylation | ||||
Reactome | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Post-translational protein phosphorylation | ||||
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (4)
Components (5)
Processes (14)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
appendicular lean mass | 5 | 1 | 6 | 84.4 | |||||
2 | 2 | 0 | 1.1 | 76 | |||||
TPE interval measurement | 1 | 2 | 2 | 63.6 | |||||
waist-hip ratio | 1 | 1 | 1 | 61.4 | |||||
BMI-adjusted waist-hip ratio | 1 | 1 | 1 | 61.4 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
appendicular lean mass | 6 | 84.4 | |||||
0 | 1.1 | 76 | |||||
TPE interval measurement | 2 | 63.6 | |||||
waist-hip ratio | 1 | 61.4 | |||||
BMI-adjusted waist-hip ratio | 1 | 61.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | stanniocalcin 2 | VGNC:4184 | 462274 | |||||
Macaque | stanniocalcin 2 | 703900 | ||||||
Mouse | MGI:1316731 | 20856 | ||||||
Rat | RGD:621777 | 63878 | ||||||
Dog | stanniocalcin 2 | VGNC:46896 | 489112 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | stanniocalcin 2 | |||||
Macaque | stanniocalcin 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | stanniocalcin 2 | |||||
Publication Statistics
PubMed Score 136.28
PubMed score by year
PubTator Score 65.45
PubTator score by year
Related Publications
Text Mined References (59)
GeneRif Annotations (45)
Items per page:
0 of 0
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