Tbio SEC14L2 SEC14-like protein 2

Protein Summary

Description

Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell. This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• O76054
• B7Z8Q1
• F5H3U4
• Q53EQ2
• Q6PD61
• Q9ULN4

Gene Name

• SEC14L2

Ensembl ID

• ENST00000402592
• ENSP00000383882
• ENSG00000100003
• ENST00000405717
• ENSP00000385186
• ENST00000615189
• ENSP00000478755

Symbol

• C22orf6
• KIAA1186
• KIAA1658
• SPF
• TAP
• TAP1
• C22orf6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.81
disease perturbation	0.79
microRNA	0.72
cell type or tissue	0.61
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.11   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 236   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.11   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0