You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NCR1
Natural cytotoxicity triggering receptor 1

Protein Summary
Description
Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350790
  • ENSP00000344358
  • ENSG00000189430
  • ENST00000357397
  • ENSP00000349972
  • ENST00000610621
  • ENSP00000483452
  • ENSG00000273535
  • ENST00000610753
  • ENSP00000484377
  • ENST00000611098
  • ENSP00000479222
  • ENSG00000275156
  • ENST00000611105
  • ENSP00000483028
  • ENSG00000278362
  • ENST00000611942
  • ENSP00000483723
  • ENST00000612239
  • ENSP00000481692
  • ENST00000612645
  • ENSP00000481540
  • ENST00000612896
  • ENSP00000484520
  • ENST00000613135
  • ENSP00000480145
  • ENST00000613556
  • ENSP00000482092
  • ENST00000615622
  • ENSP00000478507
  • ENST00000617154
  • ENSP00000481971
  • ENST00000617784
  • ENSP00000482423
  • ENST00000618973
  • ENSP00000483611
  • ENST00000619077
  • ENSP00000484221
  • ENST00000619451
  • ENSP00000482536
  • ENST00000620296
  • ENSP00000484067
  • ENST00000621059
  • ENSP00000484831
  • ENST00000621652
  • ENSP00000477625
  • ENST00000639155
  • ENSP00000491020
  • ENSG00000284113
  • ENST00000640377
  • ENSP00000491933
  • ENSG00000284208
  • ENST00000640753
  • ENSP00000492673
  • ENST00000640987
  • ENSP00000492426

Symbol
  • LY94
  • LY94
  • CD335
  • NKP46
  • NK-p46
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.72
cellular component
0.69
biological term
0.64
tissue
0.61
phenotype
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 275.66   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 684   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 275.66   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 684   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (227)
1 – 10 of 227
CD247
Tbio
Novelty: 0.00275443
Score: 0.937
Data Source: Reactome,STRINGDB
FCGR1A
Tchem
Novelty: 0.00091043
Score: 0.926
Data Source: Reactome,STRINGDB
FCER1G
Tbio
Novelty: 0.00930179
Score: 0.921
Data Source: STRINGDB
KLRK1
Tbio
Novelty: 0.00109238
Score: 0.92
Data Source: STRINGDB
NCR2
Tbio
Novelty: 0.00891474
Score: 0.92
Data Source: STRINGDB
NCR3
Tbio
Novelty: 0.00225217
Score: 0.92
Data Source: STRINGDB
KLRC1
Tbio
Novelty: 0.00383875
Score: 0.868
Data Source: STRINGDB
KLRD1
Tbio
Novelty: 0.00257574
Score: 0.851
Data Source: STRINGDB
IL15
Tbio
Novelty: 0.00081119
Score: 0.821
Data Source: STRINGDB
CD226
Tbio
Novelty: 0.00453644
Score: 0.821
Data Source: STRINGDB
Publication Statistics
PubMed Score  275.66

PubMed score by year
PubTator Score  175.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer