Tbio CLPX ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial

Protein Summary

Description

ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP (PubMed:28874591). Targets specific substrates for degradation by the Clp complex (PubMed:11923310, PubMed:22710082). Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure (PubMed:22841477). ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis (PubMed:28874591). Important for efficient erythropoiesis through upregulation of heme biosynthesis (PubMed:25957689, PubMed:28874591). The protein encoded by this gene is part of a protease found in mitochondria. This protease is ATP-dependent and targets specific proteins for degradation. The protease consists of two heptameric rings of the CLPP catalytic subunit sandwiched between two hexameric rings of the chaperone subunit encoded by this gene. Targeted proteins are unwound by this protein and then passed on to the CLPP subunit for degradation. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• O76031
• A1L428
• A8K8F1
• B9EGI8
• Q9H4D9

Gene Name

• CLPX

Ensembl ID

• ENST00000300107
• ENSP00000300107
• ENSG00000166855

Symbol

• EPP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
co-expressed gene	0.98
disease perturbation	0.97
interacting protein	0.94
kinase perturbation	0.81

Protein Classes

PANTHER Classes

Protein / Chaperone / Atp-dependent Clp Protease Atp-binding Subunit Clpx-like, Mitochondrial

DTO Classes

Protein / Chaperone / Atp-dependent Clp Protease Atp-binding Subunit Clpx-like, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 469.29   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 87   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 469.29   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0