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Tbio
CLPX
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial

Protein Classes
Protein Summary
Description
ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP (PubMed:28874591). Targets specific substrates for degradation by the Clp complex (PubMed:11923310, PubMed:22710082). Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure (PubMed:22841477). ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis (PubMed:28874591). Important for efficient erythropoiesis through upregulation of heme biosynthesis (PubMed:25957689, PubMed:28874591). The protein encoded by this gene is part of a protease found in mitochondria. This protease is ATP-dependent and targets specific proteins for degradation. The protease consists of two heptameric rings of the CLPP catalytic subunit sandwiched between two hex ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300107
  • ENSP00000300107
  • ENSG00000166855

Symbol
  • EPP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
co-expressed gene
0.98
disease perturbation
0.97
interacting protein
0.94
kinase perturbation
0.81


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 392.74   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 392.74   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
caseinolytic mitochondrial matrix peptidase chaperone subunit
VGNC:2476
748057
Macaque
caseinolytic mitochondrial matrix peptidase chaperone subunit
708954
Mouse
MGI:1346017
270166
Rat
RGD:1304883
300786
Dog
caseinolytic mitochondrial matrix peptidase chaperone subunit
VGNC:39359
609344
Species
Name
OMA
EggNOG
Inparanoid
Chimp
caseinolytic mitochondrial matrix peptidase chaperone subunit
Macaque
caseinolytic mitochondrial matrix peptidase chaperone subunit
Mouse
Rat
Dog
caseinolytic mitochondrial matrix peptidase chaperone subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O76031-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (18)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (117)
1 – 10 of 117
GPT2
Tbio
Family: Enzyme
Novelty: 0.00478585
p_int: 0.999544037
p_ni: 0.000455963
Data Source: BioPlex
NDEL1
Tbio
Novelty: 0.01241819
p_int: 0.999433475
p_ni: 0.000566525
Data Source: BioPlex
BTRC
Tbio
Novelty: 0.00293475
p_int: 0.998651973
p_ni: 0.001348027
Score: 0.513
Data Source: BioPlex,STRINGDB
THTPA
Tbio
Family: Enzyme
Novelty: 0.06922501
p_int: 0.996023378
p_ni: 0.003976622
Score: 0.243
Data Source: BioPlex,STRINGDB
CHCHD10
Tbio
Novelty: 0.01659548
p_int: 0.989256505
p_ni: 0.010743495
Score: 0.187
Data Source: BioPlex,STRINGDB
DDX54
Tbio
Family: Enzyme
Novelty: 0.12769464
p_int: 0.985693447
p_ni: 0.014306553
Data Source: BioPlex
ATPAF2
Tbio
Family: Enzyme
Novelty: 0.04184643
p_int: 0.972858164
p_ni: 0.027141836
Score: 0.206
Data Source: BioPlex,STRINGDB
FOXRED1
Tbio
Family: Enzyme
Novelty: 0.07057772
p_int: 0.963647743
p_ni: 0.036352257
Score: 0.371
Data Source: BioPlex,STRINGDB
GNS
Tbio
Family: Enzyme
Novelty: 0.01528509
p_int: 0.936902936
p_ni: 0.063097064
Score: 0.228
Data Source: BioPlex,STRINGDB
CLEC3A
Tdark
Novelty: 0.21498836
p_int: 0.892751937
p_ni: 0.107248063
Data Source: BioPlex
Publication Statistics
PubMed Score  392.74

PubMed score by year
PubTator Score  42.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer