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Tbio
ANXA9
Annexin A9

Protein Summary
Description
Low affinity receptor for acetylcholine known to be targeted by disease-causing pemphigus vulgaris antibodies in keratinocytes. The annexins are a family of calcium-dependent phospholipid-binding proteins. Members of the annexin family contain 4 internal repeat domains, each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic phospholipids and extracellular matrix proteins. This gene encodes a divergent member of the annexin protein family in which all four homologous type II calcium-binding sites in the conserved tetrad core contain amino acid substitutions that ablate their function. However, structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368947
  • ENSP00000357943
  • ENSG00000143412

Symbol
  • ANX31
  • ANX31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.85
molecular function
0.81
cell type or tissue
0.67
PubMedID
0.66
tissue sample
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.56   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.56   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
95.6
testosterone measurement
2
1
2
79.1
mathematical ability
2
1
2
68
chronotype measurement
1
1
0
1
54
bitter non-alcoholic beverage consumption measurement
1
1
1
33.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
95.6
testosterone measurement
2
79.1
mathematical ability
2
68
chronotype measurement
0
1
54
bitter non-alcoholic beverage consumption measurement
1
33.2
Gene Ontology Terms (9)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (36)
1 – 10 of 36
TRIM69
Tbio
Family: Enzyme
Novelty: 0.18807436
p_int: 0.999999935
p_ni: 6.2e-8
p_wrong: 3e-9
Score: 0.622
Data Source: BioPlex,STRINGDB
DYSF
Tbio
Novelty: 0.00248634
Score: 0.749
Data Source: STRINGDB
TMEM200B
Tdark
Novelty: 0.18113379
Score: 0.696
Data Source: STRINGDB
ACP6
Tbio
Family: Enzyme
Novelty: 0.04985294
Score: 0.681
Data Source: STRINGDB
TSG101
Tbio
Novelty: 0.00211746
Score: 0.669
Data Source: STRINGDB
CD81
Tchem
Novelty: 0.00111328
Score: 0.669
Data Source: STRINGDB
CD63
Tchem
Novelty: 0.00072515
Score: 0.668
Data Source: STRINGDB
CD9
Tbio
Novelty: 0.00095308
Score: 0.644
Data Source: STRINGDB
AHNAK
Tbio
Novelty: 0.01201996
Score: 0.631
Data Source: STRINGDB
CD82
Tbio
Novelty: 0.00146542
Score: 0.576
Data Source: STRINGDB
Publication Statistics
PubMed Score  55.56

PubMed score by year
PubTator Score  7.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer