Protein Summary
Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. This gene encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations in this gene are associated with Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), an autosomal recessive disorder. The disease affects the brain and central nervous system. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
- ENST00000226760
- ENSP00000226760
- ENSG00000109501
- ENST00000503569
- ENSP00000423337
- WFS
- WFRS
- WFSL
- CTRCT41
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.99 | ||
disease perturbation | 0.83 | ||
biological term | 0.77 | ||
phenotype | 0.77 | ||
transcription factor perturbation | 0.68 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 347.54 (req: < 5)
Gene RIFs: 121 (req: <= 3)
Antibodies: 145 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 347.54 (req: >= 5)
Gene RIFs: 121 (req: > 3)
Antibodies: 145 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 34
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
9 | 4 | 1 | 1.1 | 97.3 | |||||
Drugs used in diabetes use measurement | 1 | 1 | 1 | 52.6 | |||||
response to cisplatin | 1 | 1 | 0 | 5.4 | 33.4 | ||||
ototoxicity | 1 | 1 | 0 | 5.4 | 33.4 | ||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
1 | 1.1 | 97.3 | |||||
Drugs used in diabetes use measurement | 1 | 52.6 | |||||
response to cisplatin | 0 | 5.4 | 33.4 | ||||
ototoxicity | 0 | 5.4 | 33.4 | ||||
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | wolframin ER transmembrane glycoprotein | 710948 | ||||||
Mouse | MGI:1328355 | 22393 | ||||||
Rat | RGD:68954 | 83725 | ||||||
Dog | wolframin ER transmembrane glycoprotein | VGNC:48407 | 482113 | |||||
Horse | wolframin ER transmembrane glycoprotein | VGNC:25031 | 100070117 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | wolframin ER transmembrane glycoprotein | |||||
Mouse | ||||||
Rat | ||||||
Dog | wolframin ER transmembrane glycoprotein | |||||
Horse | wolframin ER transmembrane glycoprotein | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (8)
Reactome (7)
KEGG (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 7
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | IRE1alpha activates chaperones | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Reactome | Post-translational protein phosphorylation | ||||
Reactome | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
IRE1alpha activates chaperones | ||||
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Post-translational protein phosphorylation | ||||
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Gene Ontology Terms (41)
Functions (5)
Components (7)
Processes (29)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (225)
1 – 10 of 225
ADIPOR1
Novelty: 0.00273623
p_int: 0.9092768
p_ni: 0.0907232
Score: 0.299
Data Source: BioPlex,STRINGDB
P2RX2
Family: IC
Novelty: 0.00241146
p_int: 0.854403704
p_ni: 0.145596296
Score: 0.189
Data Source: BioPlex,STRINGDB
YIPF3
Novelty: 0.12021667
p_int: 0.847528002
p_ni: 0.152471998
Score: 0.151
Data Source: BioPlex,STRINGDB
ANTXR1
Novelty: 0.00508081
p_int: 0.759535796
p_ni: 0.240464204
Score: 0.201
Data Source: BioPlex,STRINGDB
HSP90B1
Novelty: 0.00135881
Score: 0.964
Data Source: STRINGDB
DNAJC3
Novelty: 0.02129782
Score: 0.94
Data Source: STRINGDB
ATF6
Family: TF
Novelty: 0.00149266
Score: 0.935
Data Source: STRINGDB
P4HB
Family: Enzyme
Novelty: 0.00107905
Score: 0.921
Data Source: STRINGDB
GPC3
Novelty: 0.00151823
Score: 0.919
Data Source: STRINGDB
IL6
Novelty: 0.00001819
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score 347.54
PubMed score by year
PubTator Score 218.91
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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UniProt Keyword
GWAS Trait