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Tbio
WFS1
Wolframin

Protein Summary
Description
Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. This gene encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations in this gene are associated with Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), an autosomal recessive disorder. The disease affects the brain and central nervous system. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226760
  • ENSP00000226760
  • ENSG00000109501
  • ENST00000503569
  • ENSP00000423337

Symbol
  • WFS
  • WFRS
  • WFSL
  • CTRCT41
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
disease perturbation
0.83
biological term
0.77
phenotype
0.77
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 347.54   (req: < 5)
Gene RIFs: 121   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 347.54   (req: >= 5)
Gene RIFs: 121   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
4
1
1.1
97.3
Drugs used in diabetes use measurement
1
1
1
52.6
response to cisplatin
1
1
0
5.4
33.4
ototoxicity
1
1
0
5.4
33.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
97.3
Drugs used in diabetes use measurement
1
52.6
response to cisplatin
0
5.4
33.4
ototoxicity
0
5.4
33.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
wolframin ER transmembrane glycoprotein
710948
Mouse
MGI:1328355
22393
Rat
RGD:68954
83725
Dog
wolframin ER transmembrane glycoprotein
VGNC:48407
482113
Horse
wolframin ER transmembrane glycoprotein
VGNC:25031
100070117
Species
Name
OMA
EggNOG
Inparanoid
Macaque
wolframin ER transmembrane glycoprotein
Mouse
Rat
Dog
wolframin ER transmembrane glycoprotein
Horse
wolframin ER transmembrane glycoprotein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O76024-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
IRE1alpha activates chaperones (R-HSA-381070)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
IRE1alpha activates chaperones
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Gene Ontology Terms (41)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (225)
1 – 10 of 225
ADIPOR1
Tbio
Novelty: 0.00273623
p_int: 0.9092768
p_ni: 0.0907232
Score: 0.299
Data Source: BioPlex,STRINGDB
P2RX2
Tchem
Family: IC
Novelty: 0.00241146
p_int: 0.854403704
p_ni: 0.145596296
Score: 0.189
Data Source: BioPlex,STRINGDB
YIPF3
Tbio
Novelty: 0.12021667
p_int: 0.847528002
p_ni: 0.152471998
Score: 0.151
Data Source: BioPlex,STRINGDB
ANTXR1
Tbio
Novelty: 0.00508081
p_int: 0.759535796
p_ni: 0.240464204
Score: 0.201
Data Source: BioPlex,STRINGDB
HSP90B1
Tchem
Novelty: 0.00135881
Score: 0.964
Data Source: STRINGDB
DNAJC3
Tbio
Novelty: 0.02129782
Score: 0.94
Data Source: STRINGDB
ATF6
Tbio
Family: TF
Novelty: 0.00149266
Score: 0.935
Data Source: STRINGDB
P4HB
Tbio
Family: Enzyme
Novelty: 0.00107905
Score: 0.921
Data Source: STRINGDB
GPC3
Tbio
Novelty: 0.00151823
Score: 0.919
Data Source: STRINGDB
IL6
Tclin
Novelty: 0.00001819
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score  347.54

PubMed score by year
PubTator Score  218.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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