Tbio RSL1D1 Ribosomal L1 domain-containing protein 1

Protein Summary

Description

Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.

Uniprot Accession IDs

• O76021
• B4DJ58
• D3DUG7
• Q2M1T7
• Q6PL22
• Q8IWS7
• Q8WUZ1
• Q9HDA9
• Q9Y3Z9

Gene Name

• RSL1D1

Ensembl ID

• ENST00000571133
• ENSP00000460871
• ENSG00000171490

Symbol

• CATX11
• CSIG
• PBK1
• L12
• CSIG
• PBK1
• UTP30

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
drug perturbation	0.96
disease perturbation	0.95
virus perturbation	0.95
histone modification site profile	0.9

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / Ribosomal L1 Domain-containing Protein 1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / Ribosomal L1 Domain-containing Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.26   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 133   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.26   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0