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Tdark
KRT37
Keratin, type I cuticular Ha7

Protein Summary
Description
The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225550
  • ENSP00000225550
  • ENSG00000108417
  • ENST00000574588
  • ENSP00000458693
  • ENSG00000263022

Symbol
  • HHA7
  • HKA7
  • KRTHA7
  • HA7
  • K37
  • KRTHA7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.58
tissue
0.54
co-expressed gene
0.48
cell line
0.45
cellular component
0.45


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.5   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 29   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.5   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
49.5
hair color
2
2
0
1.2
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
49.5
hair color
0
1.2
48.5
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin 37
VGNC:12377
743918
Macaque
keratin, type I cuticular Ha7
706274
Opossum
keratin, type I cuticular Ha8-like
100013884
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin 37
Macaque
keratin, type I cuticular Ha7
Opossum
keratin, type I cuticular Ha8-like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O76014-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (55)
1 – 10 of 55
KRT81
Tbio
Novelty:  0.05514238
Score:  0.929
Data Source:  STRINGDB
KRT85
Tbio
Novelty:  0.09341199
Score:  0.927
Data Source:  STRINGDB
KRT78
Tbio
Novelty:  0.08006367
Score:  0.927
Data Source:  STRINGDB
KRT6C
Tbio
Novelty:  0.11659743
Score:  0.927
Data Source:  STRINGDB
KRT82
Tdark
Novelty:  0.5488139
Score:  0.926
Data Source:  STRINGDB
KRT76
Tdark
Novelty:  0.87892674
Score:  0.926
Data Source:  STRINGDB
KRT74
Tbio
Novelty:  0.12747273
Score:  0.926
Data Source:  STRINGDB
KRT80
Tbio
Novelty:  0.08480792
Score:  0.925
Data Source:  STRINGDB
KRT79
Tbio
Novelty:  0.07935891
Score:  0.924
Data Source:  STRINGDB
KRT6B
Tbio
Novelty:  0.00152754
Score:  0.924
Data Source:  STRINGDB
Publication Statistics
PubMed Score  42.50

PubMed score by year
PubTator Score  24.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer