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Tdark
KRT36
Keratin, type I cuticular Ha6

Protein Summary
Description
The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328119
  • ENSP00000329165
  • ENSG00000126337
  • ENST00000393986
  • ENSP00000377555

Symbol
  • HHA6
  • HKA6
  • KRTHA6
  • HA6
  • hHa6
  • KRTHA6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.68
cell type or tissue
0.63
protein domain
0.58
cellular component
0.54
gene perturbation
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.18   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.18   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
KRT86
Tbio
Novelty:  0.01021995
Score:  0.934
Data Source:  STRINGDB
KRT85
Tbio
Novelty:  0.09341199
Score:  0.932
Data Source:  STRINGDB
KRT79
Tbio
Novelty:  0.07935891
Score:  0.931
Data Source:  STRINGDB
KRT75
Tbio
Novelty:  0.00937304
Score:  0.931
Data Source:  STRINGDB
KRT82
Tdark
Novelty:  0.5488139
Score:  0.931
Data Source:  STRINGDB
KRT84
Tdark
Novelty:  0.23563823
Score:  0.931
Data Source:  STRINGDB
KRT78
Tbio
Novelty:  0.08006367
Score:  0.93
Data Source:  STRINGDB
KRT77
Tbio
Novelty:  0.01331186
Score:  0.929
Data Source:  STRINGDB
KRT1
Tbio
Novelty:  0.00278467
Score:  0.928
Data Source:  STRINGDB
KRT81
Tbio
Novelty:  0.05514238
Score:  0.927
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
49.5
hair color
1
1
0
1.2
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
49.5
hair color
0
1.2
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin 36
VGNC:9360
743594
Macaque
keratin 36
706724
Mouse
MGI:109364
16673
Rat
RGD:1305792
287698
Dog
keratin 36
VGNC:42527
490984
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin 36
Macaque
keratin 36
Mouse
Rat
Dog
keratin 36
Publication Statistics
PubMed Score 2.18
PubMed score by year
PubTator Score 26.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title