Tdark KRT33A Keratin, type I cuticular Ha3-I

Protein Summary

Description

This gene encodes a member of the keratin gene family. This gene is one of multiple type I hair keratin genes that are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. As a type I hair keratin, the encoded protein is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, keratin 33A and keratin 33B. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• O76009
• B2RA87
• Q6NTB9
• Q6ZZB9

Gene Name

• KRT33A

Ensembl ID

• ENST00000007735
• ENSP00000007735
• ENSG00000006059
• ENST00000576236
• ENSP00000461221
• ENSG00000261986

Symbol

• HHA3-I
• HKA3A
• KRTHA3A
• HA3I
• K33A
• Ha-3I
• Krt1-3
• hHa3-I
• KRTHA3A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
cell type or tissue	0.78
cell line	0.53
chemical	0.41
protein domain	0.41

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.73   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 86   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.73   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0