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Tbio
GLRX3
Glutaredoxin-3

Protein Summary
Description
Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation (PubMed:23615448). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants hav ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331244
  • ENSP00000330836
  • ENSG00000108010
  • ENST00000368644
  • ENSP00000357633
  • ENST00000481034
  • ENSP00000435445

Symbol
  • PICOT
  • TXNL2
  • GRX3
  • GRX4
  • GLRX4
  • PICOT
  • TXNL2
  • TXNL3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.91
transcription factor perturbation
0.8
disease perturbation
0.79
molecular function
0.79
transcription factor
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.79   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 330   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.79   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 330   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (2)
Iron uptake and transport (R-HSA-917937)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Iron uptake and transport
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Iron uptake and transport
Transport of small molecules
Gene Ontology Terms (19)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (131)
1 – 10 of 131
CIAPIN1
Tbio
Novelty: 0.01359005
p_int: 0.999997386
p_ni: 0.000002614
Score: 0.995
Data Source: BioPlex,STRINGDB
BOLA1
Tbio
Novelty: 0.1092583
p_int: 0.999995025
p_ni: 0.000004975
Score: 0.98
Data Source: BioPlex,STRINGDB
RGS20
Tbio
Novelty: 0.04087618
p_int: 0.999993154
p_ni: 0.000006846
Score: 0.445
Data Source: BioPlex,STRINGDB
RRM1
Tclin
Family: Enzyme
Novelty: 0.00083196
p_int: 0.999990513
p_ni: 0.000009487
Score: 0.311
Data Source: BioPlex,STRINGDB
KLRG2
Tdark
Novelty: 1.19446694
p_int: 0.999965695
p_ni: 0.000034305
Score: 0.455
Data Source: BioPlex,STRINGDB
AHNAK2
Tbio
Novelty: 0.05663435
p_int: 0.989550601
p_ni: 0.010449399
Data Source: BioPlex
NDOR1
Tbio
Family: Enzyme
Novelty: 0.07400532
p_int: 0.979438283
p_ni: 0.020561717
Score: 0.585
Data Source: BioPlex,STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
p_int: 0.929896251
p_ni: 0.070093172
p_wrong: 0.000010577
Data Source: BioPlex
NAA40
Tbio
Family: Enzyme
Novelty: 0.13882523
p_int: 0.884316784
p_ni: 0.115683216
Score: 0.193
Data Source: BioPlex,STRINGDB
GNAZ
Tbio
Novelty: 0.02008523
p_int: 0.7958059
p_ni: 0.189972379
p_wrong: 0.014221721
Score: 0.159
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  119.79

PubMed score by year
PubTator Score  52.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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