Tbio GLRX3 Glutaredoxin-3

Protein Summary

Description

Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation (PubMed:23615448). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• O76003
• B3KMP7
• B3KMQ5
• D3DRG2
• Q5JV01
• Q96CE0
• Q9P1B0
• Q9P1B1

Gene Name

• GLRX3

Ensembl ID

• ENST00000331244
• ENSP00000330836
• ENSG00000108010
• ENST00000368644
• ENSP00000357633
• ENST00000481034
• ENSP00000435445

Symbol

• PICOT
• TXNL2
• GRX3
• GRX4
• GLRX4
• PICOT
• TXNL2
• TXNL3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.91
transcription factor perturbation	0.8
disease perturbation	0.79
molecular function	0.79
transcription factor	0.74

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Glutaredoxin-3

DTO Classes

Protein / Enzyme / Oxidoreductase / Reductase / Glutaredoxin-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 392.55   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 330   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 392.55   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 330   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0