Tdark OR2J3 Olfactory receptor 2J3

Protein Summary

Description

Odorant receptor involved in the detection of the flavor compound cis-3-hexen-1-ol (C3HEX), a compound typically described as 'green grassy' or the smell of 'cut grass'. This gene encodes a G-protein-coupled receptor (GPCR) that functions as an olfactory receptor. Olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell. The protein encoded by this gene responds to cis-3-hexen-1-ol, which is released by wounded plants, including cut grass. This gene is situated in a cluster of similar olfactory-receptor coding genes on chromosome 6. [provided by RefSeq, May 2013]

Uniprot Accession IDs

• O76001
• B0UY52
• B9EH11
• Q5SUJ7
• Q6IF25
• Q96R15
• Q9GZK5
• Q9GZL4
• Q9GZL5

Gene Name

• OR2J3

Ensembl ID

• ENST00000377169
• ENSP00000366374
• ENSG00000204701
• ENST00000383651
• ENSP00000373147
• ENSG00000206522
• ENST00000414140
• ENSP00000390144
• ENSG00000232178
• ENST00000418630
• ENSP00000400546
• ENSG00000233618
• ENST00000419260
• ENSP00000408783
• ENSG00000229866
• ENST00000428081
• ENSP00000388392
• ENSG00000226271
• ENST00000430478
• ENSP00000388205
• ENSG00000233636

Symbol

• 6M1-3
• OR6-6
• C3HEXS
• OR6-16
• ORL671
• HS6M1-3
• OR6.3.6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.85
cell line	0.5
tissue sample	0.46
protein domain	0.41
microRNA	0.35

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.09   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 83   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.09   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (7)

Reactome (5)

KEGG (1)

WikiPathways (1)

G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	G alpha (s) signalling events	577 targets	R-HSA-418555
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	Olfactory Signaling Pathway	431 targets	R-HSA-381753
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by GPCR	1212 targets	R-HSA-372790

Name	Explore in Pharos	Explore in Source
G alpha (s) signalling events	577 targets	R-HSA-418555
GPCR downstream signalling	1152 targets	R-HSA-388396
Olfactory Signaling Pathway	431 targets	R-HSA-381753
Signal Transduction	2704 targets	R-HSA-162582
Signaling by GPCR	1212 targets	R-HSA-372790

Gene Ontology Terms (4)

Functions (2)

Components (2)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
olfactory receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
G protein-coupled receptor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (29)

Explore Interacting Targets

1 – 10 of 29

• See Interactions on String-DB

RTP2

Tbio

Novelty: 0.13129103

Score: 0.94

Data Source: STRINGDB

RTP1

Tbio

Novelty: 0.04761905

Score: 0.921

Data Source: STRINGDB

REEP1

Tbio

Novelty: 0.02999447

Score: 0.921

Data Source: STRINGDB

GNAL

Tbio

Novelty: 0.0277957

Score: 0.917

Data Source: STRINGDB

GNB1

Tbio

Novelty: 0.04716243

Score: 0.9

Data Source: STRINGDB

REEP6

Tbio

Novelty: 0.17493781

Score: 0.9

Data Source: STRINGDB

RTP3

Tbio

Novelty: 0.12230635

Score: 0.9

Data Source: STRINGDB

REEP2

Tdark

Novelty: 0.28121006

Score: 0.9

Data Source: STRINGDB

REEP4

Tbio

Novelty: 0.34354551

Score: 0.9

Data Source: STRINGDB

RTP4

Tbio

Novelty: 0.18444058

Score: 0.9

Data Source: STRINGDB

Publication Statistics

PubMed Score  3.09

PubMed score by year

Reset Zoom

PubTator Score  47.78

PubTator score by year

Reset Zoom

Patents

Reset Zoom

Amino Acid Sequence

Residue Counts

Sequence

MNDDGKVNASSEGYFILVGFSNWPHLEVVIFVVVLIFYLMTLIGNLFIIILSYLDSHLHTPMYFFLSNLS

1-70

FLDLCYTTSSIPQLLVNLWGPEKTISYAGCMIQLYFVLALGTTECVLLVVMSYDRYAAVCRPLHYTVLMH

70-140

PRFCHLLAVASWVSGFTNSALHSSFTFWVPLCGHRQVDHFFCEVPALLRLSCVDTHVNELTLMITSSIFV

140-210

LIPLILILTSYGAIVRAVLRMQSTTGLQKVFGTCGAHLMAVSLFFIPAMCIYLQPPSGNSQDQGKFIALF

210-280

YTVVTPSLNPLIYTLRNKVVRGAVKRLMGWE

280-311

MNDDGKVNASSEGYFILVGFSNWPHLEVVIFVVVLIFYLMTLIGNLFIIILSYLDSHLHTPMYFFLSNLSFLDLCYTTSSIPQLLVNLWGPEKTISYAGCMIQLYFVLALGTTECVLLVVMSYDRYAAVCRPLHYTVLMHPRFCHLLAVASWVSGFTNSALHSSFTFWVPLCGHRQVDHFFCEVPALLRLSCVDTHVNELTLMITSSIFVLIPLILILTSYGAIVRAVLRMQSTTGLQKVFGTCGAHLMAVSLFFIPAMCIYLQPPSGNSQDQGKFIALFYTVVTPSLNPLIYTLRNKVVRGAVKRLMGWE

Find similar targets by:

Uniprot Keyword

Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Olfaction
Polymorphism
Receptor
Reference proteome