Tbio OR2J3 Olfactory receptor 2J3

Protein Summary

Description

Odorant receptor involved in the detection of the flavor compound cis-3-hexen-1-ol (C3HEX), a compound typically described as 'green grassy' or the smell of 'cut grass'. This gene encodes a G-protein-coupled receptor (GPCR) that functions as an olfactory receptor. Olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell. The protein encoded by this gene responds to cis-3-hexen-1-ol, which is released by wounded plants, including cut grass. This gene is situated in a cluster of similar olfactory-receptor coding genes on chromosome 6. [provided by RefSeq, May 2013]

Uniprot Accession IDs

• O76001
• B0UY52
• B9EH11
• Q5SUJ7
• Q6IF25
• Q96R15
• Q9GZK5
• Q9GZL4
• Q9GZL5

Gene Name

• OR2J3

Ensembl ID

• ENST00000377169
• ENSP00000366374
• ENSG00000204701
• ENST00000383651
• ENSP00000373147
• ENSG00000206522
• ENST00000414140
• ENSP00000390144
• ENSG00000232178
• ENST00000418630
• ENSP00000400546
• ENSG00000233618
• ENST00000419260
• ENSP00000408783
• ENSG00000229866
• ENST00000428081
• ENSP00000388392
• ENSG00000226271
• ENST00000430478
• ENSP00000388205
• ENSG00000233636

Symbol

• 6M1-3
• OR6-6
• C3HEXS
• OR6-16
• ORL671
• HS6M1-3
• OR6.3.6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.85
cell line	0.5
tissue sample	0.46
protein domain	0.41
microRNA	0.35

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Olfactory Receptor / Olfactory Receptor 2j3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.7   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 83   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.7   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0