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Tbio
CPD
Carboxypeptidase D

Protein Summary
Description
The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225719
  • ENSP00000225719
  • ENSG00000108582
  • ENST00000543464
  • ENSP00000444443

Symbol
  • GP180
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
PubMedID
0.87
microRNA
0.85
disease perturbation
0.74
transcription factor binding site profile
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.27   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.27   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (80)
1 – 10 of 80
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.9021488
p_ni:  0.0978512
Data Source:  BioPlex
UFSP2
Tbio
Family:  Enzyme
Novelty:  0.12630722
p_int:  0.902121985
p_ni:  0.097878015
Score:  0.158
Data Source:  BioPlex,STRINGDB
FOXK2
Tbio
Family:  TF
Novelty:  0.01420141
p_int:  0.894129004
p_ni:  0.105416673
p_wrong:  0.000454323
Score:  0.189
Data Source:  BioPlex,STRINGDB
TNF
Tclin
Novelty:  0.00001457
p_int:  0.851475825
p_ni:  0.148524175
Score:  0.173
Data Source:  BioPlex,STRINGDB
AP1M1
Tbio
Novelty:  0.029282
p_int:  0.846661469
p_ni:  0.153338531
Score:  0.946
Data Source:  BioPlex,STRINGDB
TGOLN2
Tbio
Novelty:  0.005107
Score:  0.952
Data Source:  STRINGDB
IGF2R
Tchem
Novelty:  0.00138374
Score:  0.946
Data Source:  STRINGDB
SORT1
Tchem
Novelty:  0.00319862
Score:  0.935
Data Source:  STRINGDB
AP1G1
Tbio
Novelty:  0.03754132
Score:  0.92
Data Source:  STRINGDB
AP1M2
Tbio
Novelty:  0.02984354
Score:  0.915
Data Source:  STRINGDB
Pathways (4)
Golgi Associated Vesicle Biogenesis (R-HSA-432722)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Reactome
trans-Golgi Network Vesicle Budding
Name
Explore in Pharos
Explore in Source
Golgi Associated Vesicle Biogenesis
Membrane Trafficking
Vesicle-mediated transport
trans-Golgi Network Vesicle Budding
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
59.4
high density lipoprotein cholesterol measurement
1
1
1
57.3
self reported educational attainment
1
1
1
40.7
smoking status measurement
1
1
1
24.5
apolipoprotein A 1 measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
59.4
high density lipoprotein cholesterol measurement
1
57.3
self reported educational attainment
1
40.7
smoking status measurement
1
24.5
apolipoprotein A 1 measurement
1
21.5
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carboxypeptidase D
VGNC:12054
454557
Mouse
MGI:107265
12874
Rat
RGD:2393
25306
Dog
carboxypeptidase D
VGNC:39551
480636
Horse
carboxypeptidase D
VGNC:16814
100072234
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carboxypeptidase D
Mouse
Rat
Dog
carboxypeptidase D
Horse
carboxypeptidase D
Publication Statistics
PubMed Score 45.27
PubMed score by year
PubTator Score 64.64
PubTator score by year