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Tdark
SNAPC5
snRNA-activating protein complex subunit 5

Protein Summary
Description
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. This gene encodes a subunit of the small nuclear RNA (snRNA)-activating protein complex that plays a role in the transcription of snRNA genes. This complex binds to the promoters of snRNA genes transcribed by either RNA polymerase II or III and recruits other regulatory factors to activate snRNA gene transcription. The encoded protein may play a role in stabilizing this complex. A pseudogene of this gene has been identified on chromosome 6. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307979
  • ENSP00000308439
  • ENSG00000174446
  • ENST00000316634
  • ENSP00000319597
  • ENST00000395589
  • ENSP00000378954
  • ENST00000562411
  • ENSP00000454421
  • ENST00000563480
  • ENSP00000457892

Symbol
  • SNAP19
  • SNAP19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.93
virus perturbation
0.92
gene perturbation
0.68
histone modification site profile
0.59
cell type or tissue
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.35   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.35   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (111)
SNAPC1
Tbio
Novelty:  0.18444701
p_int:  0.999985996
p_ni:  3.9e-8
p_wrong:  0.000013964
Score:  0.992
Data Source:  BioPlex,STRINGDB
SNAPC4
Tbio
Family:  TF
Novelty:  0.09720791
Score:  0.989
Data Source:  STRINGDB
SNAPC2
Tdark
Novelty:  0.26291137
Score:  0.986
Data Source:  STRINGDB
SNAPC3
Tbio
Novelty:  0.11748003
Score:  0.984
Data Source:  STRINGDB
POLR3D
Tbio
Family:  Enzyme
Novelty:  0.02616321
Score:  0.963
Data Source:  STRINGDB
POLR3H
Tbio
Family:  Enzyme
Novelty:  0.16483597
Score:  0.963
Data Source:  STRINGDB
POLR3C
Tbio
Family:  Enzyme
Novelty:  0.05778457
Score:  0.956
Data Source:  STRINGDB
POLR3F
Tbio
Family:  Enzyme
Novelty:  0.0805125
Score:  0.952
Data Source:  STRINGDB
POLR3E
Tbio
Family:  Enzyme
Novelty:  0.06500715
Score:  0.948
Data Source:  STRINGDB
POLR1C
Tbio
Family:  Enzyme
Novelty:  0.04485332
Score:  0.947
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase III Abortive And Retractive Initiation
Reactome
RNA Polymerase III Transcription
Reactome
RNA Polymerase III Transcription Initiation
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase II Transcription
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Transcription
RNA Polymerase III Transcription Initiation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
2
3
87.5
triglyceride measurement
3
2
3
63.6
mean platelet volume
1
1
1
56.4
mathematical ability
1
1
1
56.4
body mass index
1
1
1
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
87.5
triglyceride measurement
3
63.6
mean platelet volume
1
56.4
mathematical ability
1
56.4
body mass index
1
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
small nuclear RNA activating complex polypeptide 5
VGNC:3527
100612370
Macaque
small nuclear RNA activating complex polypeptide 5
710777
Mouse
MGI:1914282
330959
Rat
RGD:1582813
691501
Dog
small nuclear RNA activating complex polypeptide 5
VGNC:46594
610865
Species
Name
OMA
EggNOG
Inparanoid
Chimp
small nuclear RNA activating complex polypeptide 5
Macaque
small nuclear RNA activating complex polypeptide 5
Mouse
Rat
Dog
small nuclear RNA activating complex polypeptide 5
Publication Statistics
PubMed Score 1.35
PubMed score by year
PubTator Score 0.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title