Tdark SNAPC5 snRNA-activating protein complex subunit 5

Protein Summary

Description

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. This gene encodes a subunit of the small nuclear RNA (snRNA)-activating protein complex that plays a role in the transcription of snRNA genes. This complex binds to the promoters of snRNA genes transcribed by either RNA polymerase II or III and recruits other regulatory factors to activate snRNA gene transcription. The encoded protein may play a role in stabilizing this complex. A pseudogene of this gene has been identified on chromosome 6. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• O75971
• A8K7N6
• Q96CF3
• SNAPc subunit 5

Gene Name

• SNAPC5

Ensembl ID

• ENST00000307979
• ENSP00000308439
• ENSG00000174446
• ENST00000316634
• ENSP00000319597
• ENST00000395589
• ENSP00000378954
• ENST00000562411
• ENSP00000454421
• ENST00000563480
• ENSP00000457892

Symbol

• SNAP19
• SNAP19

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.93
virus perturbation	0.92
gene perturbation	0.68
histone modification site profile	0.59
cell type or tissue	0.54

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.94   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 124   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.94   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0