MPDZ
Multiple PDZ domain protein
Protein Summary
Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. The protein encoded by this gene has multiple PDZ domains, which are hallmarks of protein-protein interactions. The encoded protein is known to interact with the HTR2C receptor and may cause it to clump at the cell surface. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
- ENST00000319217
- ENSP00000320006
- ENSG00000107186
- ENST00000381022
- ENSP00000370410
- ENST00000447879
- ENSP00000415208
- ENST00000536827
- ENSP00000444151
- ENST00000541718
- ENSP00000439807
- MUPP1
- HYC2
- MUPP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.79 | ||
disease perturbation | 0.74 | ||
gene perturbation | 0.73 | ||
PubMedID | 0.68 | ||
cell type or tissue | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 73.76 (req: < 5)
Gene RIFs: 28 (req: <= 3)
Antibodies: 75 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 73.76 (req: >= 5)
Gene RIFs: 28 (req: > 3)
Antibodies: 75 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0