Tbio TRIO Triple functional domain protein

Protein Summary

Description

Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:8643598, PubMed:27418539). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). This gene encodes a large protein that functions as a GDP to GTP exchange factor. This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• O75962
• D3DTD1
• Q13458
• Q59EQ7
• Q6PJC9
• Q6ZN05
• Q8IWK8

Gene Name

• TRIO

Ensembl ID

• ENST00000344135
• ENSP00000339291
• ENSG00000038382
• ENST00000344204
• ENSP00000339299

Symbol

• tgat
• MEBAS
• MRD44
• ARHGEF23

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
kinase perturbation	0.96
molecular function	0.96
transcription factor perturbation	0.91
transcription factor binding site profile	0.9

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Triple Functional Domain Protein

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Trio Family / Triple Functional Domain Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.55   (req: < 5)

Gene RIFs: 42   (req: <= 3)

Antibodies: 50   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.55   (req: >= 5)

Gene RIFs: 42   (req: > 3)

Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0