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Tbio
FLOT1
Flotillin-1

Protein Summary
Description
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. This gene encodes an protein that localizes to the caveolae, which are small domains on the inner cell membranes. This protein plays a role in vesicle trafficking and cell morphology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376389
  • ENSP00000365569
  • ENSG00000137312
  • ENST00000383382
  • ENSP00000372873
  • ENSG00000206379
  • ENST00000383562
  • ENSP00000373056
  • ENSG00000206480
  • ENST00000436822
  • ENSP00000391438
  • ENSG00000232280
  • ENST00000444632
  • ENSP00000388861
  • ENSG00000230143
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
0.99
kinase perturbation
0.88
transcription factor perturbation
0.84
cellular component
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.83   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 374   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.83   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 374   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
50.6
1
1
0
1.2
50.6
1
1
0
1.2
50.6
1
1
0
1.2
50.6
intelligence
1
1
0
5.6
17.8
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
50.6
0
1.2
50.6
0
1.2
50.6
0
1.2
50.6
intelligence
0
5.6
17.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
flotillin 1
VGNC:11080
471961
Macaque
flotillin 1
714175
Mouse
MGI:1100500
14251
Rat
RGD:70991
64665
Dog
flotillin 1
VGNC:40903
474831
Species
Name
OMA
EggNOG
Inparanoid
Chimp
flotillin 1
Macaque
flotillin 1
Mouse
Rat
Dog
flotillin 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75955-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Reactome
Synaptic adhesion-like molecules
Name
Explore in Pharos
Explore in Source
Neuronal System
Protein-protein interactions at synapses
Synaptic adhesion-like molecules
Protein-Protein Interactions (96)
1 – 10 of 96
DNAL4
Tbio
Novelty: 0.15546154
p_int: 0.867575371
p_ni: 0.132424629
Data Source: BioPlex
SYNJ2BP
Tbio
Novelty: 0.02520087
p_int: 0.764511549
p_ni: 0.235488451
Data Source: BioPlex
GORASP2
Tbio
Novelty: 0.02121907
p_int: 0.751504255
p_ni: 0.248495745
Score: 0.622
Data Source: BioPlex,STRINGDB
CAV1
Tbio
Novelty: 0.00035244
Score: 0.975
Data Source: STRINGDB
FLOT2
Tbio
Novelty: 0.00727325
Score: 0.968
Data Source: STRINGDB
CDH1
Tbio
Novelty: 0.00010629
Score: 0.926
Data Source: STRINGDB
LRFN3
Tdark
Novelty: 0.30018245
Score: 0.925
Data Source: STRINGDB
SLC6A3
Tclin
Family: Transporter
Novelty: 0.00017601
Score: 0.919
Data Source: STRINGDB
SORBS1
Tbio
Novelty: 0.01480301
Score: 0.886
Data Source: STRINGDB
PTOV1
Tbio
Novelty: 0.04624884
Score: 0.877
Data Source: STRINGDB
Publication Statistics
PubMed Score  193.83

PubMed score by year
PubTator Score  125.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer