Protein Summary
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. This gene encodes an protein that localizes to the caveolae, which are small domains on the inner cell membranes. This protein plays a role in vesicle trafficking and cell morphology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
- ENST00000376389
- ENSP00000365569
- ENSG00000137312
- ENST00000383382
- ENSP00000372873
- ENSG00000206379
- ENST00000383562
- ENSP00000373056
- ENSG00000206480
- ENST00000436822
- ENSP00000391438
- ENSG00000232280
- ENST00000444632
- ENSP00000388861
- ENSG00000230143
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
interacting protein | 0.99 | ||
kinase perturbation | 0.88 | ||
transcription factor perturbation | 0.84 | ||
cellular component | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 230 (req: < 5)
Gene RIFs: 80 (req: <= 3)
Antibodies: 374 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 230 (req: >= 5)
Gene RIFs: 80 (req: > 3)
Antibodies: 374 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 31
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0