Tbio RAD17 Cell cycle checkpoint protein RAD17

Protein Summary

Description

Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination. The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• O75943
• A8K8X2
• D3DWA5
• O75714
• Q7Z3S4
• Q9UNK7
• Q9UNR7
• Q9UNR8
• Q9UPF5
• hRad17

Gene Name

• RAD17

Ensembl ID

• ENST00000282891
• ENSP00000282891
• ENSG00000152942
• ENST00000305138
• ENSP00000303134
• ENST00000345306
• ENSP00000311227
• ENST00000354312
• ENSP00000346271
• ENST00000354868
• ENSP00000346938
• ENST00000358030
• ENSP00000350725
• ENST00000361732
• ENSP00000355226
• ENST00000380774
• ENSP00000370151
• ENST00000509734
• ENSP00000426191
• ENST00000521422
• ENSP00000427743
• ENST00000610770
• ENSP00000478167
• ENSG00000276618
• ENST00000611523
• ENSP00000477962
• ENST00000612044
• ENSP00000477996
• ENST00000616488
• ENSP00000484854
• ENST00000616683
• ENSP00000482775
• ENST00000616759
• ENSP00000479160
• ENST00000620889
• ENSP00000482371

Symbol

• R24L
• CCYC
• R24L
• RAD24
• HRAD17
• RAD17SP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.89
disease perturbation	0.87
virus perturbation	0.85
hub protein	0.82
transcription factor perturbation	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.93   (req: < 5)

Gene RIFs: 33   (req: <= 3)

Antibodies: 585   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.93   (req: >= 5)

Gene RIFs: 33   (req: > 3)

Antibodies: 585   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0