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Tbio
RAD17
Cell cycle checkpoint protein RAD17

Protein Summary
Description
Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination. The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphor ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282891
  • ENSP00000282891
  • ENSG00000152942
  • ENST00000305138
  • ENSP00000303134
  • ENST00000345306
  • ENSP00000311227
  • ENST00000354312
  • ENSP00000346271
  • ENST00000354868
  • ENSP00000346938
  • ENST00000358030
  • ENSP00000350725
  • ENST00000361732
  • ENSP00000355226
  • ENST00000380774
  • ENSP00000370151
  • ENST00000509734
  • ENSP00000426191
  • ENST00000521422
  • ENSP00000427743
  • ENST00000610770
  • ENSP00000478167
  • ENSG00000276618
  • ENST00000611523
  • ENSP00000477962
  • ENST00000612044
  • ENSP00000477996
  • ENST00000616488
  • ENSP00000484854
  • ENST00000616683
  • ENSP00000482775
  • ENST00000616759
  • ENSP00000479160
  • ENST00000620889
  • ENSP00000482371

Symbol
  • R24L
  • CCYC
  • R24L
  • RAD24
  • HRAD17
  • RAD17SP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
disease perturbation
0.87
virus perturbation
0.85
hub protein
0.82
transcription factor perturbation
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.25   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 585   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.25   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 585   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (38)
Items per page:
1 – 5 of 38
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
3
3
94.3
neutrophil count
3
3
3
94.3
myeloid white cell count
2
2
2
90.1
myeloid white cell count
2
2
2
90.1
leukocyte count
2
2
2
86.1
Items per page:
1 – 5 of 38
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
94.3
neutrophil count
3
94.3
myeloid white cell count
2
90.1
myeloid white cell count
2
90.1
leukocyte count
2
86.1
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAD17 checkpoint clamp loader component
VGNC:13575
461832
Macaque
RAD17 checkpoint clamp loader component
700116
Mouse
MGI:1333807
19356
Rat
RGD:1309515
310034
Dog
RAD17 checkpoint clamp loader component
VGNC:45311
478088
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAD17 checkpoint clamp loader component
Macaque
RAD17 checkpoint clamp loader component
Mouse
Rat
Dog
RAD17 checkpoint clamp loader component
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75943-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (28)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Cell Cycle
Cell Cycle Checkpoints
DNA Double-Strand Break Repair
DNA Repair
Gene Ontology Terms (17)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (202)
1 – 10 of 202
RFC4
Tbio
Novelty:  0.03232586
p_int:  1
Score:  0.998
Data Source:  BioPlex,STRINGDB
RFC5
Tbio
Novelty:  0.03987481
p_int:  0.999999999
p_ni:  1e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
HUS1
Tbio
Novelty:  0.00837493
p_int:  0.999996519
p_ni:  0.00000347
p_wrong:  1.1e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
PIP
Tbio
Novelty:  0.00208509
p_int:  0.997123997
p_ni:  0.002455992
p_wrong:  0.000420012
Data Source:  BioPlex
RFC3
Tbio
Novelty:  0.02712951
p_int:  0.991357788
p_ni:  0.008642212
Score:  0.999
Data Source:  BioPlex,STRINGDB
RFC2
Tbio
Novelty:  0.02088405
p_int:  0.903946085
p_ni:  0.096053915
Score:  0.999
Data Source:  BioPlex,STRINGDB
ATM
Tchem
Family:  Kinase
Novelty:  0.00019169
Score:  0.997
Data Source:  STRINGDB
CLSPN
Tbio
Novelty:  0.01330727
Score:  0.997
Data Source:  STRINGDB
ATR
Tchem
Family:  Kinase
Novelty:  0.00196978
Score:  0.996
Data Source:  STRINGDB
RAD9A
Tbio
Novelty:  0.00560195
Score:  0.995
Data Source:  STRINGDB
Publication Statistics
PubMed Score  146.25

PubMed score by year
PubTator Score  74.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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