Tbio SMNDC1 Survival of motor neuron-related-splicing factor 30

Protein Summary

Description

Necessary for spliceosome assembly. Overexpression causes apoptosis. This gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. The protein encoded by this gene is a nuclear protein that has been identified as a constituent of the spliceosome complex. This gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75940
• B2RA27
• D3DRB1
• Q5T3K6

Gene Name

• SMNDC1

Ensembl ID

• ENST00000369592
• ENSP00000358605
• ENSG00000119953
• ENST00000369603
• ENSP00000358616

Symbol

• SMNR
• SPF30
• SMNR
• SPF30
• TDRD16C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.96
disease perturbation	0.93
transcription factor binding site profile	0.9
transcription factor perturbation	0.74
histone modification site profile	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.56   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 269   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.56   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0