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Tbio
DNAJC8
DnaJ homolog subfamily C member 8

Protein Summary
Description
Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells (PubMed:27133716).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263697
  • ENSP00000263697
  • ENSG00000126698
  • ENST00000645856
  • ENSP00000494062
  • ENSG00000285317

Symbol
  • SPF31
  • SPF31
  • HSPC331
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
1
kinase perturbation
0.97
gene perturbation
0.78
virus perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.71   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.71   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (243)
PHF5A
Tbio
Family:  Epigenetic
Novelty:  0.02989472
p_int:  0.945502334
p_ni:  0.054497666
Score:  0.927
Data Source:  BioPlex,STRINGDB
SF3A2
Tbio
Novelty:  0.03658692
Score:  0.993
Data Source:  STRINGDB
CTNNBL1
Tbio
Novelty:  0.0189038
Score:  0.951
Data Source:  STRINGDB
PRPF40A
Tbio
Novelty:  0.00898047
Score:  0.949
Data Source:  STRINGDB
SRSF2
Tbio
Novelty:  0.00207072
Score:  0.948
Data Source:  STRINGDB
SNRPF
Tdark
Novelty:  0.17624854
Score:  0.944
Data Source:  STRINGDB
SNRPD2
Tbio
Novelty:  0.02519503
Score:  0.944
Data Source:  STRINGDB
U2AF2
Tbio
Novelty:  0.00590935
Score:  0.944
Data Source:  STRINGDB
PTBP1
Tbio
Novelty:  0.00184728
Score:  0.942
Data Source:  STRINGDB
SNRPG
Tbio
Novelty:  0.1684808
Score:  0.941
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
1
0
7.3
58.4
aspartate aminotransferase measurement
1
1
0
7.3
58.4
hematocrit
2
1
2
47.7
hematocrit
2
1
2
47.7
uric acid measurement
1
1
1
26.6
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
0
7.3
58.4
aspartate aminotransferase measurement
0
7.3
58.4
hematocrit
2
47.7
hematocrit
2
47.7
uric acid measurement
1
26.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C8
VGNC:10602
469250
Macaque
DnaJ heat shock protein family (Hsp40) member C8
720231
Mouse
MGI:1915848
68598
Rat
RGD:1306024
313035
Dog
DnaJ heat shock protein family (Hsp40) member C8
VGNC:52131
478166
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C8
Macaque
DnaJ heat shock protein family (Hsp40) member C8
Mouse
Rat
Dog
DnaJ heat shock protein family (Hsp40) member C8
Publication Statistics
PubMed Score 3.71
PubMed score by year
PubTator Score 2.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title