You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
BBOX1
Gamma-butyrobetaine dioxygenase

Protein Summary
Description
Catalyzes the formation of L-carnitine from gamma-butyrobetaine. This gene encodes gamma butyrobetaine hydroxylase which catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthetic pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta-oxidation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263182
  • ENSP00000263182
  • ENSG00000129151
  • ENST00000525090
  • ENSP00000433772
  • ENST00000528583
  • ENSP00000434918
  • ENST00000529202
  • ENSP00000435781

Symbol
  • BBH
  • BBOX
  • BBH
  • BBOX
  • G-BBH
  • gamma-BBH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
cell type or tissue
0.7
disease
0.69
PubMedID
0.65
phenotype
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.25   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 334   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.25   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 334   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Carnitine synthesis (R-HSA-71262)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carnitine synthesis
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Carnitine synthesis
Metabolism
Metabolism of amino acids and derivatives
Gene Ontology Terms (9)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (141)
1 – 10 of 141
AZI2
Tbio
Novelty: 0.23255317
p_int: 0.999999707
p_ni: 2.93e-7
Score: 0.237
Data Source: BioPlex,STRINGDB
CASP2
Tchem
Family: Enzyme
Novelty: 0.00189892
p_int: 0.999998359
p_ni: 2e-9
p_wrong: 0.000001639
Score: 0.237
Data Source: BioPlex,STRINGDB
TBK1
Tchem
Family: Kinase
Novelty: 0.00194753
p_int: 0.999997818
p_ni: 0.000002182
Score: 0.643
Data Source: BioPlex,STRINGDB
TANK
Tbio
Novelty: 0.01003866
p_int: 0.999997348
p_ni: 0.000002637
p_wrong: 1.6e-8
Score: 0.309
Data Source: BioPlex,STRINGDB
ITPRID2
Tbio
Novelty: 0.07923791
p_int: 0.999926009
p_ni: 0.000073991
Data Source: BioPlex
POLR3F
Tbio
Family: Enzyme
Novelty: 0.0805125
p_int: 0.999799121
p_ni: 0.00020082
p_wrong: 5.9e-8
Score: 0.325
Data Source: BioPlex,STRINGDB
RTFDC1
Tbio
Novelty: 0.06569762
p_int: 0.999776168
p_ni: 0.000223832
Score: 0.237
Data Source: BioPlex,STRINGDB
PRKN
Tbio
Family: Enzyme
Novelty: 0.00079898
p_int: 0.988534574
p_ni: 0.011465426
Score: 0.243
Data Source: BioPlex,STRINGDB
PCBP3
Tbio
Novelty: 0.11681812
p_int: 0.979327792
p_ni: 0.015916685
p_wrong: 0.004755523
Score: 0.154
Data Source: BioPlex,STRINGDB
ITPR2
Tbio
Family: IC
Novelty: 0.00619813
p_int: 0.887852592
p_ni: 0.112147408
Score: 0.177
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  336.25

PubMed score by year
PubTator Score  55.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: