BBOX1
Gamma-butyrobetaine dioxygenase
Protein Summary
Catalyzes the formation of L-carnitine from gamma-butyrobetaine. This gene encodes gamma butyrobetaine hydroxylase which catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthetic pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta-oxidation. [provided by RefSeq, Jul 2008]
- ENST00000263182
- ENSP00000263182
- ENSG00000129151
- ENST00000525090
- ENSP00000433772
- ENST00000528583
- ENSP00000434918
- ENST00000529202
- ENSP00000435781
- BBH
- BBOX
- BBH
- BBOX
- G-BBH
- gamma-BBH
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.85 | ||
cell type or tissue | 0.7 | ||
disease | 0.69 | ||
PubMedID | 0.65 | ||
phenotype | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 455.68 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 334 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 455.68 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 334 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 9
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0