Protein Summary
Together with dynein may be involved in spindle assembly and cytokinesis. This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
- ENST00000259632
- ENSP00000259632
- ENSG00000137100
- ENST00000341694
- ENSP00000343986
- ENST00000378916
- ENSP00000368196
- DCTN22
- DCTN22
- DCTN-22
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 1 | ||
kinase perturbation | 0.99 | ||
virus perturbation | 0.83 | ||
cellular component | 0.79 | ||
interacting protein | 0.73 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.21 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 185 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.21 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 185 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (33)
Reactome (33)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 33
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | AURKA Activation by TPX2 | ||||
Reactome | Adaptive Immune System | ||||
Reactome | Anchoring of the basal body to the plasma membrane | ||||
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | COPI-independent Golgi-to-ER retrograde traffic | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
AURKA Activation by TPX2 | ||||
Adaptive Immune System | ||||
Anchoring of the basal body to the plasma membrane | ||||
Asparagine N-linked glycosylation | ||||
COPI-independent Golgi-to-ER retrograde traffic | ||||
Gene Ontology Terms (19)
Functions (1)
Components (10)
Processes (8)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (313)
1 – 10 of 313
DCTN5
Novelty: 0.30523995
p_int: 0.999947901
p_ni: 0.000052099
Score: 0.946
Data Source: BioPlex,Reactome,STRINGDB
DCTN2
Novelty: 0.01298814
p_int: 0.999916035
p_ni: 0.000083965
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
DCTN1
Novelty: 0.00789738
p_int: 0.99986763
p_ni: 0.00013237
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
DCTN6
Novelty: 0.93301435
p_int: 0.999521148
p_ni: 0.000478743
p_wrong: 1.09e-7
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
CAPZA2
Novelty: 0.27435063
p_int: 0.998435351
p_ni: 0.001564648
p_wrong: 1e-9
Score: 0.951
Data Source: BioPlex,Reactome,STRINGDB
RIC8A
Novelty: 0.01968858
p_int: 0.997683624
p_ni: 0.002316376
Score: 0.699
Data Source: BioPlex,STRINGDB
DEFB127
Novelty: 0.21093001
p_int: 0.994601085
p_ni: 0.005398915
Score: 0.817
Data Source: BioPlex,STRINGDB
ACTR1A
Novelty: 0.1045483
p_int: 0.99429513
p_ni: 0.00570487
Score: 0.946
Data Source: BioPlex,Reactome,STRINGDB
ACTR1B
Novelty: 0.15424927
p_int: 0.993809453
p_ni: 0.006190547
Score: 0.996
Data Source: BioPlex,STRINGDB
N4BP2L1
Novelty: 1
p_int: 0.989863699
p_ni: 0.010136301
Data Source: BioPlex
Publication Statistics
PubMed Score 4.21
PubMed score by year
PubTator Score 3.78
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MAGLTDLQRLQARVEELERWVYGPGGARGSRKVADGLVKVQVALGNISSKRERVKILYKKIEDLIKYLDP
1-70
EYIDRIAIPDASKLQFILAEEQFILSQVALLEQVNALVPMLDSAHIKAVPEHAARLQRLAQIHIQQQDQC
70-140
VEITEESKALLEEYNKTTMLLSKQFVQWDELLCQLEAATQVKPAEE
140-186
MAGLTDLQRLQARVEELERWVYGPGGARGSRKVADGLVKVQVALGNISSKRERVKILYKKIEDLIKYLDPEYIDRIAIPDASKLQFILAEEQFILSQVALLEQVNALVPMLDSAHIKAVPEHAARLQRLAQIHIQQQDQCVEITEESKALLEEYNKTTMLLSKQFVQWDELLCQLEAATQVKPAEE
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