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Tdark
DCTN3
Dynactin subunit 3

Protein Summary
Description
Together with dynein may be involved in spindle assembly and cytokinesis. This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259632
  • ENSP00000259632
  • ENSG00000137100
  • ENST00000341694
  • ENSP00000343986
  • ENST00000378916
  • ENSP00000368196

Symbol
  • DCTN22
  • DCTN22
  • DCTN-22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.99
virus perturbation
0.83
cellular component
0.79
interacting protein
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.21   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.21   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (33)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Adaptive Immune System
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Adaptive Immune System
Anchoring of the basal body to the plasma membrane
Asparagine N-linked glycosylation
COPI-independent Golgi-to-ER retrograde traffic
Gene Ontology Terms (19)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (313)
1 – 10 of 313
DCTN5
Tdark
Novelty: 0.30523995
p_int: 0.999947901
p_ni: 0.000052099
Score: 0.946
Data Source: BioPlex,Reactome,STRINGDB
DCTN2
Tbio
Novelty: 0.01298814
p_int: 0.999916035
p_ni: 0.000083965
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
DCTN1
Tbio
Novelty: 0.00789738
p_int: 0.99986763
p_ni: 0.00013237
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
DCTN6
Tdark
Novelty: 0.93301435
p_int: 0.999521148
p_ni: 0.000478743
p_wrong: 1.09e-7
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
CAPZA2
Tdark
Novelty: 0.27435063
p_int: 0.998435351
p_ni: 0.001564648
p_wrong: 1e-9
Score: 0.951
Data Source: BioPlex,Reactome,STRINGDB
RIC8A
Tbio
Novelty: 0.01968858
p_int: 0.997683624
p_ni: 0.002316376
Score: 0.699
Data Source: BioPlex,STRINGDB
DEFB127
Tbio
Novelty: 0.21093001
p_int: 0.994601085
p_ni: 0.005398915
Score: 0.817
Data Source: BioPlex,STRINGDB
ACTR1A
Tbio
Novelty: 0.1045483
p_int: 0.99429513
p_ni: 0.00570487
Score: 0.946
Data Source: BioPlex,Reactome,STRINGDB
ACTR1B
Tbio
Novelty: 0.15424927
p_int: 0.993809453
p_ni: 0.006190547
Score: 0.996
Data Source: BioPlex,STRINGDB
N4BP2L1
Tdark
Novelty: 1
p_int: 0.989863699
p_ni: 0.010136301
Data Source: BioPlex
Publication Statistics
PubMed Score  4.21

PubMed score by year
PubTator Score  3.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer