Tdark DCTN3 Dynactin subunit 3

Protein Summary

Description

Together with dynein may be involved in spindle assembly and cytokinesis. This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• O75935
• A6NII7
• B2RBM5
• Q5T1I5
• Q5T1I7
• Q5T8G3
• Q9BPU8

Gene Name

• DCTN3

Ensembl ID

• ENST00000259632
• ENSP00000259632
• ENSG00000137100
• ENST00000341694
• ENSP00000343986
• ENST00000378916
• ENSP00000368196

Symbol

• DCTN22
• DCTN22
• DCTN-22

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	0.99
virus perturbation	0.83
cellular component	0.79
interacting protein	0.73

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.21   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 185   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.21   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (33)

Reactome (33)

AURKA Activation by TPX2 (R-HSA-8854518)

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Items per page:

5

1 – 5 of 33

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	AURKA Activation by TPX2	72 targets	R-HSA-8854518
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Reactome	Asparagine N-linked glycosylation	286 targets	R-HSA-446203
Reactome	COPI-independent Golgi-to-ER retrograde traffic	34 targets	R-HSA-6811436

Name	Explore in Pharos	Explore in Source
AURKA Activation by TPX2	72 targets	R-HSA-8854518
Adaptive Immune System	894 targets	R-HSA-1280218
Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Asparagine N-linked glycosylation	286 targets	R-HSA-446203
COPI-independent Golgi-to-ER retrograde traffic	34 targets	R-HSA-6811436

Gene Ontology Terms (19)

Functions (1)

Components (10)

Processes (8)

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
structural molecule activity	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (313)

Explore Interacting Targets

1 – 10 of 313

• See Interactions on String-DB

DCTN5

Tdark

Novelty: 0.30523995

p_int: 0.999947901

p_ni: 0.000052099

Score: 0.946

Data Source: BioPlex,Reactome,STRINGDB

DCTN2

Tbio

Novelty: 0.01298814

p_int: 0.999916035

p_ni: 0.000083965

Score: 0.995

Data Source: BioPlex,Reactome,STRINGDB

DCTN1

Tbio

Novelty: 0.00789738

p_int: 0.99986763

p_ni: 0.00013237

Score: 0.998

Data Source: BioPlex,Reactome,STRINGDB

DCTN6

Tdark

Novelty: 0.93301435

p_int: 0.999521148

p_ni: 0.000478743

p_wrong: 1.09e-7

Score: 0.995

Data Source: BioPlex,Reactome,STRINGDB

CAPZA2

Tdark

Novelty: 0.27435063

p_int: 0.998435351

p_ni: 0.001564648

p_wrong: 1e-9

Score: 0.951

Data Source: BioPlex,Reactome,STRINGDB

RIC8A

Tbio

Novelty: 0.01968858

p_int: 0.997683624

p_ni: 0.002316376

Score: 0.699

Data Source: BioPlex,STRINGDB

DEFB127

Tbio

Novelty: 0.21093001

p_int: 0.994601085

p_ni: 0.005398915

Score: 0.817

Data Source: BioPlex,STRINGDB

ACTR1A

Tbio

Novelty: 0.1045483

p_int: 0.99429513

p_ni: 0.00570487

Score: 0.946

Data Source: BioPlex,Reactome,STRINGDB

ACTR1B

Tbio

Novelty: 0.15424927

p_int: 0.993809453

p_ni: 0.006190547

Score: 0.996

Data Source: BioPlex,STRINGDB

N4BP2L1

Tdark

Novelty: 1

p_int: 0.989863699

p_ni: 0.010136301

Data Source: BioPlex

Publication Statistics

PubMed Score  4.21

PubMed score by year

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PubTator Score  3.78

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MAGLTDLQRLQARVEELERWVYGPGGARGSRKVADGLVKVQVALGNISSKRERVKILYKKIEDLIKYLDP

1-70

EYIDRIAIPDASKLQFILAEEQFILSQVALLEQVNALVPMLDSAHIKAVPEHAARLQRLAQIHIQQQDQC

70-140

VEITEESKALLEEYNKTTMLLSKQFVQWDELLCQLEAATQVKPAEE

140-186

MAGLTDLQRLQARVEELERWVYGPGGARGSRKVADGLVKVQVALGNISSKRERVKILYKKIEDLIKYLDPEYIDRIAIPDASKLQFILAEEQFILSQVALLEQVNALVPMLDSAHIKAVPEHAARLQRLAQIHIQQQDQCVEITEESKALLEEYNKTTMLLSKQFVQWDELLCQLEAATQVKPAEE

Find similar targets by:

Uniprot Keyword

Acetylation
Alternative splicing
Cell cycle
Cell division
Centromere
Chromosome
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton