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Tbio
PIAS1
E3 SUMO-protein ligase PIAS1

Protein Summary
Description
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249636
  • ENSP00000249636
  • ENSG00000033800
  • ENST00000545237
  • ENSP00000438574

Symbol
  • DDXBP1
  • GBP
  • ZMIZ3
  • DDXBP1
  • GU/RH-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
molecular function
0.96
disease perturbation
0.95
biological process
0.94
kinase perturbation
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.42   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 338   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.42   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 338   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (191)
TRIM35
Tbio
Novelty:  0.03280419
p_int:  0.800273568
p_ni:  0.000002052
p_wrong:  0.199724381
Score:  0.294
Data Source:  BioPlex,STRINGDB
UBE2I
Tbio
Novelty:  0.00267883
Score:  0.997
Data Source:  STRINGDB
SUMO1
Tbio
Novelty:  0.00137629
Score:  0.992
Data Source:  Reactome,STRINGDB
STAT1
Tchem
Family:  TF
Novelty:  0.0003383
Score:  0.99
Data Source:  Reactome,STRINGDB
SUMO2
Tbio
Novelty:  0.00366833
Score:  0.99
Data Source:  STRINGDB
BRCA1
Tchem
Novelty:  0.00011146
Score:  0.979
Data Source:  STRINGDB
SUMO3
Tbio
Novelty:  0.03096465
Score:  0.979
Data Source:  STRINGDB
AR
Tclin
Family:  NR
Novelty:  0.00013531
Score:  0.966
Data Source:  STRINGDB
SATB2
Tbio
Family:  TF
Novelty:  0.00405935
Score:  0.952
Data Source:  STRINGDB
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.95
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (65)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
DNA Repair
Reactome
Formation of Incision Complex in GG-NER
Reactome
Global Genome Nucleotide Excision Repair (GG-NER)
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
DNA Repair
Formation of Incision Complex in GG-NER
Global Genome Nucleotide Excision Repair (GG-NER)
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (31)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
74
IGF-1 measurement
1
1
1
62.1
eosinophil percentage of leukocytes
1
1
1
61.4
hemoglobin measurement
2
2
2
60.8
eosinophil count
1
1
1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
74
IGF-1 measurement
1
62.1
eosinophil percentage of leukocytes
1
61.4
hemoglobin measurement
2
60.8
eosinophil count
1
59
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein inhibitor of activated STAT 1
VGNC:13418
467715
Macaque
protein inhibitor of activated STAT 1
693445
Mouse
MGI:1913125
56469
Rat
RGD:1307843
300772
Dog
protein inhibitor of activated STAT 1
VGNC:44519
478350
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein inhibitor of activated STAT 1
Macaque
protein inhibitor of activated STAT 1
Mouse
Rat
Dog
protein inhibitor of activated STAT 1
Publication Statistics
PubMed Score 115.42
PubMed score by year
PubTator Score 89.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title