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Tbio
PIAS1
E3 SUMO-protein ligase PIAS1

Protein Summary
Description
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249636
  • ENSP00000249636
  • ENSG00000033800
  • ENST00000545237
  • ENSP00000438574

Symbol
  • DDXBP1
  • GBP
  • ZMIZ3
  • DDXBP1
  • GU/RH-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
molecular function
0.96
disease perturbation
0.95
biological process
0.94
kinase perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.72   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 338   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.72   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 338   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
1
1
32.2
diastolic blood pressure
1
1
1
30.3
eosinophil count
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
32.2
diastolic blood pressure
1
30.3
eosinophil count
1
30.2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (65)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
DNA Repair
Reactome
Formation of Incision Complex in GG-NER
Reactome
Global Genome Nucleotide Excision Repair (GG-NER)
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
DNA Repair
Formation of Incision Complex in GG-NER
Global Genome Nucleotide Excision Repair (GG-NER)
Immune System
Gene Ontology Terms (31)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (191)
1 – 10 of 191
TRIM35
Tbio
Novelty: 0.03280419
p_int: 0.800273568
p_ni: 0.000002052
p_wrong: 0.199724381
Score: 0.294
Data Source: BioPlex,STRINGDB
UBE2I
Tbio
Novelty: 0.00267883
Score: 0.997
Data Source: STRINGDB
SUMO1
Tbio
Novelty: 0.00137629
Score: 0.992
Data Source: Reactome,STRINGDB
STAT1
Tchem
Family: TF
Novelty: 0.0003383
Score: 0.99
Data Source: Reactome,STRINGDB
SUMO2
Tbio
Novelty: 0.00366833
Score: 0.99
Data Source: STRINGDB
BRCA1
Tchem
Novelty: 0.00011146
Score: 0.979
Data Source: STRINGDB
SUMO3
Tbio
Novelty: 0.03096465
Score: 0.979
Data Source: STRINGDB
AR
Tclin
Family: NR
Novelty: 0.00013531
Score: 0.966
Data Source: STRINGDB
SATB2
Tbio
Family: TF
Novelty: 0.00405935
Score: 0.952
Data Source: STRINGDB
ESR1
Tclin
Family: NR
Novelty: 0.00005938
Score: 0.95
Data Source: STRINGDB
Publication Statistics
PubMed Score  109.72

PubMed score by year
PubTator Score  89.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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