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Tdark
SERF1A
Small EDRK-rich factor 1

Protein Summary
Description
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is the centromeric copy which is identical to the telomeric copy. Alternatively spliced transcripts have been documented but it is unclear whether alternative splicing occurs for both the centromeric and telomeric copies of the gene. The gene encodes a protein of unknown function which bears low-level homology with the RNA-binding domain of matrin-cyclophilin, a protein which colocalizes with small nuclear ribonucleoproteins (snRNPs) and the SMN1 gene product. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317633
  • ENSP00000321791
  • ENSG00000172058
  • ENST00000354833
  • ENSP00000346892
  • ENST00000380750
  • ENSP00000370126
  • ENSG00000205572
  • ENST00000380751
  • ENSP00000370127
  • ENST00000611616
  • ENSP00000482392
  • ENSG00000278839
  • ENST00000613172
  • ENSP00000484795
  • ENSG00000277429
  • ENST00000614527
  • ENSP00000479724
  • ENSG00000275581
  • ENST00000621283
  • ENSP00000481118
  • ENST00000622553
  • ENSP00000480543
  • ENST00000627372
  • ENSP00000487374
  • ENST00000630567
  • ENSP00000487531

Symbol
  • FAM2A
  • SERF1
  • SMAM1
  • h4F5
  • FAM2B
  • H4F5C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.76
tissue sample
0.7
transcription factor perturbation
0.68
PubMedID
0.63
microRNA
0.61


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.3   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 17   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.3   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 17   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75920-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (18)
1 – 10 of 18
NDUFAF3
Tclin
Family: Enzyme
Novelty: 0.00063584
Score: 0.836
Data Source: STRINGDB
C1S
Tchem
Novelty: 0.00043003
Score: 0.766
Data Source: STRINGDB
NAIP
Tbio
Novelty: 0.00400896
Score: 0.718
Data Source: STRINGDB
BDP1
Tbio
Novelty: 0.00497963
Score: 0.711
Data Source: STRINGDB
F2
Tclin
Family: Enzyme
Novelty: 0.00004833
Score: 0.67
Data Source: STRINGDB
HNRNPH3
Tbio
Novelty: 0.11764945
Score: 0.64
Data Source: STRINGDB
GTF2H2
Tbio
Novelty: 0.02761619
Score: 0.588
Data Source: STRINGDB
SMN1
Tbio
Family: Epigenetic
Novelty: 0.0008085
Score: 0.584
Data Source: STRINGDB
MT-ND3
Tclin
Family: Enzyme
Novelty: 0.00161513
Score: 0.553
Data Source: STRINGDB
CD82
Tbio
Novelty: 0.00146542
Score: 0.527
Data Source: STRINGDB
Publication Statistics
PubMed Score  259.30

PubMed score by year
PubTator Score  3.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer