Tbio SERF1A Small EDRK-rich factor 1

Protein Summary

Description

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is the centromeric copy which is identical to the telomeric copy. Alternatively spliced transcripts have been documented but it is unclear whether alternative splicing occurs for both the centromeric and telomeric copies of the gene. The gene encodes a protein of unknown function which bears low-level homology with the RNA-binding domain of matrin-cyclophilin, a protein which colocalizes with small nuclear ribonucleoproteins (snRNPs) and the SMN1 gene product. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75920
• B7ZKM2
• O75919
• Q52LK5

Gene Name

• SERF1A

Ensembl ID

• ENST00000317633
• ENSP00000321791
• ENSG00000172058
• ENST00000354833
• ENSP00000346892
• ENST00000380750
• ENSP00000370126
• ENSG00000205572
• ENST00000380751
• ENSP00000370127
• ENST00000611616
• ENSP00000482392
• ENSG00000278839
• ENST00000613172
• ENSP00000484795
• ENSG00000277429
• ENST00000614527
• ENSP00000479724
• ENSG00000275581
• ENST00000621283
• ENSP00000481118
• ENST00000622553
• ENSP00000480543
• ENST00000627372
• ENSP00000487374
• ENST00000630567
• ENSP00000487531

Symbol

• FAM2A
• SERF1
• SMAM1
• h4F5
• FAM2B
• H4F5C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.76
tissue sample	0.7
transcription factor perturbation	0.68
PubMedID	0.63
microRNA	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 491.35   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 17   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 491.35   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 17   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0