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Tbio
RGS9
Regulator of G-protein signaling 9

Protein Summary
Description
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity). This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262406
  • ENSP00000262406
  • ENSG00000108370
  • ENST00000449996
  • ENSP00000396329

Symbol
  • PERRS
  • RGS9L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.74
protein domain
0.73
transcription factor
0.73
transcription factor binding site profile
0.69
cellular component
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.05   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.05   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
2
5
40.6
response to anti-thyroid drug
1
1
0
5.5
15.8
reticulocyte count
1
1
1
6.5
reticulocyte measurement
1
1
1
6.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
40.6
response to anti-thyroid drug
0
5.5
15.8
reticulocyte count
1
6.5
reticulocyte measurement
1
6.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regulator of G protein signaling 9
VGNC:9561
454829
Macaque
regulator of G protein signaling 9
718549
Mouse
MGI:1338824
19739
Rat
RGD:3572
29481
Dog
regulator of G protein signaling 9
VGNC:45539
490902
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regulator of G protein signaling 9
Macaque
regulator of G protein signaling 9
Mouse
Rat
Dog
regulator of G protein signaling 9
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75916-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (25)
Chaperonin-mediated protein folding (R-HSA-390466)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Inactivation, recovery and regulation of the phototransduction cascade
Name
Explore in Pharos
Explore in Source
Chaperonin-mediated protein folding
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
G alpha (i) signalling events
GPCR downstream signalling
Inactivation, recovery and regulation of the phototransduction cascade
Gene Ontology Terms (17)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (68)
1 – 10 of 68
PRPF40B
Tdark
Novelty:  0.04278291
p_int:  1
Score:  0.943
Data Source:  BioPlex,STRINGDB
GNB5
Tbio
Novelty:  0.0067714
p_int:  0.999995945
p_ni:  0.000004055
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
RBM25
Tbio
Novelty:  0.05557892
p_int:  0.999958868
p_ni:  0.000041132
Score:  0.861
Data Source:  BioPlex,STRINGDB
RGS9BP
Tbio
Novelty:  0.04608613
Score:  0.985
Data Source:  Reactome,STRINGDB
GNAT1
Tbio
Novelty:  0.03042002
Score:  0.98
Data Source:  STRINGDB
PDE6G
Tclin
Family:  Enzyme
Novelty:  0.03113994
Score:  0.974
Data Source:  STRINGDB
GNAT2
Tbio
Novelty:  0.01683655
Score:  0.969
Data Source:  STRINGDB
GNAT3
Tbio
Novelty:  0.00702357
Score:  0.969
Data Source:  STRINGDB
GNAI2
Tchem
Novelty:  0.03014729
Score:  0.941
Data Source:  STRINGDB
GNAI1
Tbio
Novelty:  0.0488971
Score:  0.941
Data Source:  STRINGDB
Publication Statistics
PubMed Score  17.05

PubMed score by year
PubTator Score  45.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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