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Tchem
PAK3
Serine/threonine-protein kinase PAK 3

Protein Summary
Description
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262836
  • ENSP00000262836
  • ENSG00000077264
  • ENST00000360648
  • ENSP00000353864
  • ENST00000372007
  • ENSP00000361077
  • ENST00000372010
  • ENSP00000361080
  • ENST00000417227
  • ENSP00000389172
  • ENST00000425146
  • ENSP00000401982
  • ENST00000446737
  • ENSP00000410853
  • ENST00000518291
  • ENSP00000428921
  • ENST00000519681
  • ENSP00000429113

Symbol
  • OPHN3
  • ARA
  • bPAK
  • MRX30
  • MRX47
  • OPHN3
  • PAK-3
  • PAK3beta
  • beta-PAK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.99
protein domain
0.85
gene perturbation
0.77
transcription factor
0.72


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.47   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 463   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.47   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 463   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
sunitinib
chemical structure image
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
p21 (RAC1) activated kinase 3
VGNC:10463
450118
Mouse
MGI:1339656
18481
Rat
RGD:3251
29433
Dog
p21 (RAC1) activated kinase 3
VGNC:53550
492067
Horse
p21 (RAC1) activated kinase 3
100054315
Species
Name
OMA
EggNOG
Inparanoid
Chimp
p21 (RAC1) activated kinase 3
Mouse
Rat
Dog
p21 (RAC1) activated kinase 3
Horse
p21 (RAC1) activated kinase 3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75914-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (54)
Activation of RAC1 (R-HSA-428540)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of RAC1
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
C-type lectin receptors (CLRs)
Reactome
CD209 (DC-SIGN) signaling
Name
Explore in Pharos
Explore in Source
Activation of RAC1
Adaptive Immune System
Axon guidance
C-type lectin receptors (CLRs)
CD209 (DC-SIGN) signaling
Gene Ontology Terms (31)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (138)
1 – 10 of 138
ARHGEF7
Tbio
Novelty: 0.00919946
p_int: 0.999999995
p_ni: 5e-9
Score: 0.973
Data Source: BioPlex,Reactome,STRINGDB
TAX1BP3
Tbio
Novelty: 0.01605171
p_int: 0.999999823
p_ni: 1.57e-7
p_wrong: 2e-8
Data Source: BioPlex
SNRNP27
Tbio
Novelty: 0.0175187
p_int: 0.999277733
p_ni: 0.000012504
p_wrong: 0.000709763
Score: 0.19
Data Source: BioPlex,STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.995
Data Source: Reactome,STRINGDB
ARHGEF6
Tbio
Novelty: 0.02162737
Score: 0.985
Data Source: STRINGDB
RAC1
Tbio
Family: Enzyme
Novelty: 0.00365325
Score: 0.978
Data Source: Reactome,STRINGDB
GIT1
Tbio
Family: Enzyme
Novelty: 0.01022741
Score: 0.975
Data Source: Reactome,STRINGDB
NCK1
Tbio
Novelty: 0.00352084
Score: 0.967
Data Source: Reactome,STRINGDB
PXN
Tbio
Novelty: 0.00082031
Score: 0.957
Data Source: STRINGDB
PAK1
Tchem
Family: Kinase
Novelty: 0.00411227
Score: 0.956
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  32.47

PubMed score by year
PubTator Score  83.75

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer