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Tbio
DGKI
Diacylglycerol kinase iota

Protein Classes
Protein Summary
Description
This gene is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases regulate the intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The specific role of the enzyme encoded by this gene is undetermined, however, it may play a crucial role in the production of phosphatidic acid in the retina or in recessive forms of retinal degeneration. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288490
  • ENSP00000288490
  • ENSG00000157680

Symbol
  • DGK-IOTA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.85
metabolite
0.83
cell type or tissue
0.76
trait
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.29   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.29   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
11
6
3
1.1
87.9
self reported educational attainment
4
3
4
81.5
risk-taking behaviour
2
2
2
71.6
BMI-adjusted waist circumference
2
3
3
70.9
body height
2
2
2
60.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
87.9
self reported educational attainment
4
81.5
risk-taking behaviour
2
71.6
BMI-adjusted waist circumference
3
70.9
body height
2
60.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
diacylglycerol kinase iota
VGNC:13646
738801
Macaque
diacylglycerol kinase iota
709578
Mouse
MGI:2443430
320127
Rat
RGD:735049
688705
Dog
diacylglycerol kinase iota
VGNC:39921
482709
Species
Name
OMA
EggNOG
Inparanoid
Chimp
diacylglycerol kinase iota
Macaque
diacylglycerol kinase iota
Mouse
Rat
Dog
diacylglycerol kinase iota
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75912-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Effects of PIP2 hydrolysis (R-HSA-114508)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Effects of PIP2 hydrolysis
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Name
Explore in Pharos
Explore in Source
Effects of PIP2 hydrolysis
G alpha (q) signalling events
GPCR downstream signalling
Hemostasis
Platelet activation, signaling and aggregation
Gene Ontology Terms (37)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (86)
1 – 10 of 86
PLCB3
Tbio
Family:  Enzyme
Novelty:  0.01388454
Score:  0.833
Data Source:  STRINGDB
CDS2
Tbio
Family:  Enzyme
Novelty:  0.13210626
Score:  0.815
Data Source:  STRINGDB
PLCD4
Tbio
Family:  Enzyme
Novelty:  0.07014141
Score:  0.808
Data Source:  STRINGDB
PLCB2
Tbio
Family:  Enzyme
Novelty:  0.00571285
Score:  0.807
Data Source:  STRINGDB
MOGAT1
Tbio
Family:  Enzyme
Novelty:  0.0503068
Score:  0.799
Data Source:  STRINGDB
PLCB4
Tbio
Family:  Enzyme
Novelty:  0.01840915
Score:  0.774
Data Source:  STRINGDB
AGPAT5
Tbio
Family:  Enzyme
Novelty:  0.23785857
Score:  0.772
Data Source:  STRINGDB
MOGAT2
Tchem
Family:  Enzyme
Novelty:  0.06314447
Score:  0.77
Data Source:  STRINGDB
CDS1
Tbio
Family:  Enzyme
Novelty:  0.08094799
Score:  0.762
Data Source:  STRINGDB
PLCB1
Tbio
Family:  Enzyme
Novelty:  0.00269771
Score:  0.761
Data Source:  STRINGDB
Publication Statistics
PubMed Score  18.29

PubMed score by year
PubTator Score  5.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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