Protein Summary
Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008]
- ENST00000389879
- ENSP00000374529
- ENSG00000090061
- CPR4
- CPR4
- IDDHDF
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 0.99 | ||
hub protein | 0.95 | ||
biological process | 0.88 | ||
transcription factor binding site profile | 0.75 | ||
virus perturbation | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 25.09 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 163 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 25.09 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 163 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (201)
CDK13
Family: Kinase
Novelty: 0.03084808
p_int: 0.939042172
p_ni: 0.060957828
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Pathways (24)
Reactome (23)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Disease | ||||
Reactome | Formation of HIV elongation complex in the absence of HIV Tat | ||||
Reactome | Formation of RNA Pol II elongation complex | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Disease | ||||
Formation of HIV elongation complex in the absence of HIV Tat | ||||
Formation of RNA Pol II elongation complex | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (24)
Functions (6)
Components (5)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Physical Interaction (IPI) | MGI | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cyclin K | VGNC:3453 | 453152 | |||||
Mouse | MGI:1276106 | 12454 | ||||||
Rat | RGD:1595690 | 500715 | ||||||
Dog | cyclin K | VGNC:38904 | 612481 | |||||
Horse | cyclin K | VGNC:16220 | 100051490 | |||||
Publication Statistics
PubMed Score 25.09
PubMed score by year
PubTator Score 20.29
PubTator score by year
Related Publications
Text Mined References (25)
GeneRif Annotations (16)
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