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Tbio
CCNK
Cyclin-K

Protein Summary
Description
Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389879
  • ENSP00000374529
  • ENSG00000090061

Symbol
  • CPR4
  • CPR4
  • IDDHDF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.99
hub protein
0.95
biological process
0.88
transcription factor binding site profile
0.75
virus perturbation
0.72


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.09   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.09   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin K
VGNC:3453
453152
Mouse
MGI:1276106
12454
Rat
RGD:1595690
500715
Dog
cyclin K
VGNC:38904
612481
Horse
cyclin K
VGNC:16220
100051490
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin K
Mouse
Rat
Dog
cyclin K
Horse
cyclin K
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75909-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Formation of HIV elongation complex in the absence of HIV Tat
Reactome
Formation of RNA Pol II elongation complex
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Disease
Formation of HIV elongation complex in the absence of HIV Tat
Formation of RNA Pol II elongation complex
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (24)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (201)
1 – 10 of 201
CDK13
Tchem
Family:  Kinase
Novelty:  0.03084808
p_int:  0.939042172
p_ni:  0.060957828
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CDK12
Tchem
Family:  Kinase
Novelty:  0.0119925
Score:  0.999
Data Source:  Reactome,STRINGDB
CDK9
Tchem
Family:  Kinase
Novelty:  0.00210218
Score:  0.996
Data Source:  Reactome,STRINGDB
CDK7
Tchem
Family:  Kinase
Novelty:  0.00322814
Score:  0.987
Data Source:  STRINGDB
POLR2A
Tbio
Family:  Enzyme
Novelty:  0.00188323
Score:  0.985
Data Source:  STRINGDB
CCNH
Tbio
Novelty:  0.00693072
Score:  0.98
Data Source:  STRINGDB
SUPT5H
Tbio
Novelty:  0.00775042
Score:  0.978
Data Source:  Reactome,STRINGDB
CTDP1
Tbio
Family:  Enzyme
Novelty:  0.01121863
Score:  0.975
Data Source:  Reactome,STRINGDB
GTF2F1
Tbio
Novelty:  0.02118098
Score:  0.963
Data Source:  STRINGDB
RTF1
Tbio
Family:  Enzyme
Novelty:  0.02255644
Score:  0.962
Data Source:  STRINGDB
Publication Statistics
PubMed Score  25.09

PubMed score by year
PubTator Score  20.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer