Tbio CCNK Cyclin-K

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Cyclin-k

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Cyclin-k

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Cyclin-k

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Cyclin-k

Protein Summary

Description

Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75909
• Q59FT6
• Q86U16
• Q96B63
• Q9NNY9

Gene Name

• CCNK

Ensembl ID

• ENST00000389879
• ENSP00000374529
• ENSG00000090061

Symbol

• CPR4
• CPR4
• IDDHDF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.99
hub protein	0.95
biological process	0.88
transcription factor binding site profile	0.75
virus perturbation	0.72

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.09   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 163   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.09   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cyclin K	VGNC:3453	453152
Mouse	cyclin K	MGI:1276106	12454
Rat	cyclin K	RGD:1595690	500715
Dog	cyclin K	VGNC:38904	612481
Horse	cyclin K	VGNC:16220	100051490

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cyclin K
Mouse	cyclin K
Rat	cyclin K
Dog	cyclin K
Horse	cyclin K

Protein Structure (8 Structures, 1 AlphaFold Model)

tutorial

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75909-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (24)

Reactome (23)

PathwayCommons (1)

Disease (R-HSA-1643685)

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Find Similar Targets

Items per page:

5

1 – 5 of 23

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Formation of HIV elongation complex in the absence of HIV Tat	48 targets	R-HSA-167152
Reactome	Formation of RNA Pol II elongation complex	61 targets	R-HSA-112382
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436

Name	Explore in Pharos	Explore in Source
Disease	1105 targets	R-HSA-1643685
Formation of HIV elongation complex in the absence of HIV Tat	48 targets	R-HSA-167152
Formation of RNA Pol II elongation complex	61 targets	R-HSA-112382
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436

Gene Ontology Terms (24)

Functions (6)

Components (5)

Processes (13)

Find Similar Targets

Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
cyclin-dependent protein serine/threonine kinase activity	Inferred from Direct Assay (IDA)	MGI
RNA polymerase II CTD heptapeptide repeat kinase activity	Inferred from Direct Assay (IDA)	MGI
protein kinase binding	Inferred from Physical Interaction (IPI)	MGI
cyclin-dependent protein serine/threonine kinase activator activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
cyclin-dependent protein serine/threonine kinase regulator activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein serine/threonine kinase activity	Traceable Author Statement (TAS)	Reactome

Protein-Protein Interactions (201)

Explore Interacting Targets

1 – 10 of 201

• See Interactions on String-DB

CDK13

Tchem

Family:  Kinase

Novelty:  0.03084808

p_int:  0.939042172

p_ni:  0.060957828

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

CDK12

Tchem

Family:  Kinase

Novelty:  0.0119925

Score:  0.999

Data Source:  Reactome,STRINGDB

CDK9

Tchem

Family:  Kinase

Novelty:  0.00210218

Score:  0.996

Data Source:  Reactome,STRINGDB

CDK7

Tchem

Family:  Kinase

Novelty:  0.00322814

Score:  0.987

Data Source:  STRINGDB

POLR2A

Tbio

Family:  Enzyme

Novelty:  0.00188323

Score:  0.985

Data Source:  STRINGDB

CCNH

Tbio

Novelty:  0.00693072

Score:  0.98

Data Source:  STRINGDB

SUPT5H

Tbio

Novelty:  0.00775042

Score:  0.978

Data Source:  Reactome,STRINGDB

CTDP1

Tbio

Family:  Enzyme

Novelty:  0.01121863

Score:  0.975

Data Source:  Reactome,STRINGDB

GTF2F1

Tbio

Novelty:  0.02118098

Score:  0.963

Data Source:  STRINGDB

RTF1

Tbio

Family:  Enzyme

Novelty:  0.02255644

Score:  0.962

Data Source:  STRINGDB

Publication Statistics

PubMed Score  25.09

PubMed score by year

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PubTator Score  20.29

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell cycle
Cell division
Complete proteome
Cyclin
Mitosis
Nucleus
Phosphoprotein
Reference proteome

MGI Phenotype Find Similar Targets

No Header	No Header
mortality/aging