Tchem SOAT2 Sterol O-acyltransferase 2

Protein Summary

Description

Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa. Summary:This gene is a member of a small family of acyl coenzyme A:cholesterol acyltransferases. The gene encodes a membrane-bound enzyme localized in the endoplasmic reticulum that produces intracellular cholesterol esters from long-chain fatty acyl CoA and cholesterol. The cholesterol esters are then stored as cytoplasmic lipid droplets inside the cell. The enzyme is implicated in cholesterol absorption in the intestine and in the assembly and secretion of apolipoprotein B-containing lipoproteins such as very low density lipoprotein (VLDL). Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75908
• F5H7W4
• I6L9H9
• Q4VB99
• Q4VBA1
• Q96TD4
• Q9UNR2

Gene Name

• SOAT2

Ensembl ID

• ENST00000301466
• ENSP00000301466
• ENSG00000167780
• ENST00000542365
• ENSP00000442234

Symbol

• ACACT2
• ACAT2
• ACAT2
• ARGP2
• ACACT2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.89
kinase perturbation	0.76
molecular function	0.76
co-expressed gene	0.69
virus perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Sterol O-acyltransferase 2

DTO Classes

Protein / Enzyme / Transferase / Acyltransferase / Sterol O-acyltransferase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.69   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 121   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.69   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 109

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0