Tclin DGAT1 Diacylglycerol O-acyltransferase 1

Protein Summary

Description

Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• O75907
• B2RWQ2
• D3DWL6
• Q96BB8

Gene Name

• DGAT1

Ensembl ID

• ENST00000528718
• ENSP00000482264
• ENSG00000185000
• ENST00000644790
• ENSP00000495489
• ENSG00000285482

Symbol

• AGRP1
• DGAT
• ARAT
• DGAT
• ARGP1
• DIAR7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	1
transcription factor binding site profile	0.84
disease perturbation	0.83
kinase perturbation	0.76
cellular component	0.72

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Diacylglycerol O-acyltransferase 1

DTO Classes

Protein / Enzyme / Transferase / Acyltransferase / Diacylglycerol O-acyltransferase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1054.58   (req: < 5)

Gene RIFs: 47   (req: <= 3)

Antibodies: 287   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1054.58   (req: >= 5)

Gene RIFs: 47   (req: > 3)

Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 941

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1