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Tclin
DGAT1
Diacylglycerol O-acyltransferase 1

Protein Summary
Description
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000528718
  • ENSP00000482264
  • ENSG00000185000
  • ENST00000644790
  • ENSP00000495489
  • ENSG00000285482

Symbol
  • AGRP1
  • DGAT
  • ARAT
  • DGAT
  • ARGP1
  • DIAR7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
transcription factor binding site profile
0.84
disease perturbation
0.83
kinase perturbation
0.76
cellular component
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 928.18   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 287   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 928.18   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 942
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
icosapent ethyl
Rendered image for icosapent ethyl
Active Ligands (942)
1 – 10 of 942
CHEMBL4453443
Rendered image for CHEMBL4453443
CHEMBL4458847
Rendered image for CHEMBL4458847
CHEMBL4452940
Rendered image for CHEMBL4452940
CHEMBL4585408
Rendered image for CHEMBL4585408
CHEMBL3342775
Rendered image for CHEMBL3342775
US9296708, 4, ARM-P4
Rendered image for US9296708, 4, ARM-P4
US9296708, 6, ARM-P8
Rendered image for US9296708, 6, ARM-P8
CHEMBL4447657
Rendered image for CHEMBL4447657
CHEMBL4091946
Rendered image for CHEMBL4091946
CHEMBL4472207
Rendered image for CHEMBL4472207
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
2
1.1
88.1
3
3
2
1.1
88.1
alkaline phosphatase measurement
1
1
1
86.2
alkaline phosphatase measurement
1
1
1
86.2
vital capacity
1
1
1
73.3
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
88.1
2
1.1
88.1
alkaline phosphatase measurement
1
86.2
alkaline phosphatase measurement
1
86.2
vital capacity
1
73.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
diacylglycerol O-acyltransferase 1
VGNC:891
464460
Macaque
diacylglycerol O-acyltransferase 1
701489
Mouse
MGI:1333825
13350
Rat
RGD:628673
84497
Dog
diacylglycerol O-acyltransferase 1
VGNC:39912
482093
Species
Name
OMA
EggNOG
Inparanoid
Chimp
diacylglycerol O-acyltransferase 1
Macaque
diacylglycerol O-acyltransferase 1
Mouse
Rat
Dog
diacylglycerol O-acyltransferase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75907-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (31)
Acyl chain remodeling of DAG and TAG (R-HSA-1482883)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodeling of DAG and TAG
Reactome
Glycerophospholipid biosynthesis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Acyl chain remodeling of DAG and TAG
Glycerophospholipid biosynthesis
Immune System
Innate Immune System
Metabolism
Gene Ontology Terms (17)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (302)
1 – 10 of 302
CLEC2B
Tbio
Novelty:  0.06581244
p_int:  0.999995578
p_ni:  0.000004422
Data Source:  BioPlex
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.999979766
p_ni:  0.000020234
Score:  0.196
Data Source:  BioPlex,STRINGDB
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.999928432
p_ni:  0.000071537
p_wrong:  3.1e-8
Data Source:  BioPlex
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
p_int:  0.998587504
p_ni:  0.001412495
Score:  0.91
Data Source:  BioPlex,STRINGDB
SLC7A1
Tbio
Family:  Transporter
Novelty:  0.00197313
p_int:  0.996837631
p_ni:  0.003031321
p_wrong:  0.000131048
Score:  0.172
Data Source:  BioPlex,STRINGDB
POMK
Tbio
Family:  Kinase
Novelty:  0.09340344
p_int:  0.992787172
p_ni:  0.007048
p_wrong:  0.000164828
Score:  0.561
Data Source:  BioPlex,STRINGDB
TMED7
Tdark
Novelty:  0.31193294
p_int:  0.953655739
p_ni:  0.032901911
p_wrong:  0.01344235
Data Source:  BioPlex
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
p_int:  0.783395003
p_ni:  0.011011229
p_wrong:  0.205593768
Data Source:  BioPlex
MOGAT1
Tbio
Family:  Enzyme
Novelty:  0.0503068
Score:  0.995
Data Source:  STRINGDB
DGAT2
Tchem
Family:  Enzyme
Novelty:  0.00488581
Score:  0.992
Data Source:  STRINGDB
Publication Statistics
PubMed Score  928.18

PubMed score by year
PubTator Score  201.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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