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Tclin
GABBR2
Gamma-aminobutyric acid type B receptor subunit 2

Protein Summary
Description
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644, PubMed:9872744, PubMed:10906333, PubMed:10773016). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9872744, PubMed:22660477). Pre-synaptic GABA receptor inhibits neu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259455
  • ENSP00000259455
  • ENSG00000136928

Symbol
  • GPR51
  • GPRC3B
  • HG20
  • GPR51
  • EIEE59
  • GPRC3B
  • NDPLHS
  • GABABR2
  • HRIHFB2099
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
protein domain
0.92
small molecule perturbation
0.71
PubMedID
0.69
phenotype
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.27   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 515   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.27   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 515   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (321)
GABBR1
Tclin
Family:  GPCR
Novelty:  0.00086493
Score:  0.989
Data Source:  Reactome,STRINGDB
HTR1A
Tclin
Family:  GPCR
Novelty:  0.00015658
Score:  0.959
Data Source:  STRINGDB
KCNJ9
Tbio
Family:  IC
Novelty:  0.02279401
Score:  0.955
Data Source:  Reactome,STRINGDB
HTR5A
Tchem
Family:  GPCR
Novelty:  0.0160551
Score:  0.95
Data Source:  STRINGDB
KCNJ3
Tchem
Family:  IC
Novelty:  0.00373765
Score:  0.949
Data Source:  Reactome,STRINGDB
KCNJ6
Tchem
Family:  IC
Novelty:  0.00330353
Score:  0.948
Data Source:  Reactome,STRINGDB
TAS2R38
Tchem
Family:  GPCR
Novelty:  0.004625
Score:  0.944
Data Source:  STRINGDB
DRD2
Tclin
Family:  GPCR
Novelty:  0.00033797
Score:  0.942
Data Source:  STRINGDB
GRM3
Tchem
Family:  GPCR
Novelty:  0.00340947
Score:  0.941
Data Source:  STRINGDB
NPBWR1
Tchem
Family:  GPCR
Novelty:  0.03520069
Score:  0.934
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (29)
Activation of G protein gated Potassium channels (R-HSA-1296041)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
Class C/3 (Metabotropic glutamate/pheromone receptors)
Reactome
G alpha (i) signalling events
Reactome
G protein gated Potassium channels
Name
Explore in Pharos
Explore in Source
Activation of G protein gated Potassium channels
Activation of GABAB receptors
Class C/3 (Metabotropic glutamate/pheromone receptors)
G alpha (i) signalling events
G protein gated Potassium channels
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin measurement
1
1
1
48.6
body mass index
1
1
1
31.9
smoking status measurement
1
1
1
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin measurement
1
48.6
body mass index
1
31.9
smoking status measurement
1
0.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type B receptor subunit 2
VGNC:13881
464609
Macaque
gamma-aminobutyric acid type B receptor subunit 2
718019
Mouse
MGI:2386030
242425
Rat
RGD:619864
83633
Dog
gamma-aminobutyric acid type B receptor subunit 2
VGNC:41049
481627
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type B receptor subunit 2
Macaque
gamma-aminobutyric acid type B receptor subunit 2
Mouse
Rat
Dog
gamma-aminobutyric acid type B receptor subunit 2
Publication Statistics
PubMed Score 92.27
PubMed score by year
PubTator Score 149.74
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title