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Tbio
ALDH1L1
Cytosolic 10-formyltetrahydrofolate dehydrogenase

Protein Summary
Description
The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273450
  • ENSP00000273450
  • ENSG00000144908
  • ENST00000393431
  • ENSP00000377081
  • ENST00000393434
  • ENSP00000377083
  • ENST00000452905
  • ENSP00000395881
  • ENST00000455064
  • ENSP00000414126
  • ENST00000472186
  • ENSP00000420293

Symbol
  • FTHFD
  • FDH
  • FTHFD
  • 10-fTHF
  • 10-FTHFDH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
0.88
kinase perturbation
0.76
trait
0.75
transcription factor
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.6   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 412   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.6   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 412   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
ALDH1L2
Tbio
Family:  Enzyme
Novelty:  0.05452547
p_int:  0.931617438
p_ni:  0.068382562
Score:  0.895
Data Source:  BioPlex,STRINGDB
CCDC88C
Tbio
Novelty:  0.0495648
p_int:  0.929212686
p_ni:  0.070787314
Score:  0.549
Data Source:  BioPlex,STRINGDB
SHMT1
Tbio
Family:  Enzyme
Novelty:  0.00200739
Score:  0.961
Data Source:  STRINGDB
MTHFD1
Tchem
Family:  Enzyme
Novelty:  0.0071938
Score:  0.956
Data Source:  STRINGDB
SHMT2
Tchem
Family:  Enzyme
Novelty:  0.00234505
Score:  0.952
Data Source:  STRINGDB
GART
Tclin
Novelty:  0.00524985
Score:  0.951
Data Source:  STRINGDB
MTHFD2
Tchem
Family:  Enzyme
Novelty:  0.01776594
Score:  0.945
Data Source:  STRINGDB
DHFR
Tclin
Family:  Enzyme
Novelty:  0.00074557
Score:  0.941
Data Source:  STRINGDB
FTCD
Tbio
Family:  Enzyme
Novelty:  0.02266041
Score:  0.936
Data Source:  STRINGDB
MTR
Tbio
Family:  Enzyme
Novelty:  0.0006987
Score:  0.936
Data Source:  STRINGDB
Pathways (20)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of folate and pterines
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of folate and pterines
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glycine measurement
4
2
4
90.3
urate measurement
3
3
3
70.5
glomerular filtration rate
1
1
1
61.4
serum metabolite measurement
2
1
2
59.6
homocysteine measurement
1
1
1
56.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glycine measurement
4
90.3
urate measurement
3
70.5
glomerular filtration rate
1
61.4
serum metabolite measurement
2
59.6
homocysteine measurement
1
56.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
aldehyde dehydrogenase 1 family member L1
716977
Mouse
MGI:1340024
107747
Rat
RGD:621294
64392
Horse
aldehyde dehydrogenase 1 family member L1
VGNC:15232
100061108
Cow
aldehyde dehydrogenase 1 family member L1
VGNC:25811
505677
Species
Name
OMA
EggNOG
Inparanoid
Macaque
aldehyde dehydrogenase 1 family member L1
Mouse
Rat
Horse
aldehyde dehydrogenase 1 family member L1
Cow
aldehyde dehydrogenase 1 family member L1
Publication Statistics
PubMed Score 97.60
PubMed score by year
PubTator Score 98.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title