ALDH1L1
Cytosolic 10-formyltetrahydrofolate dehydrogenase
Protein Summary
The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
- ENST00000273450
- ENSP00000273450
- ENSG00000144908
- ENST00000393431
- ENSP00000377081
- ENST00000393434
- ENSP00000377083
- ENST00000452905
- ENSP00000395881
- ENST00000455064
- ENSP00000414126
- ENST00000472186
- ENSP00000420293
- FTHFD
- FDH
- FTHFD
- 10-fTHF
- 10-FTHFDH
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
transcription factor perturbation | 0.88 | ||
kinase perturbation | 0.76 | ||
trait | 0.75 | ||
transcription factor | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 97.6 (req: < 5)
Gene RIFs: 22 (req: <= 3)
Antibodies: 412 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 97.6 (req: >= 5)
Gene RIFs: 22 (req: > 3)
Antibodies: 412 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (51)
ALDH1L2
Family: Enzyme
Novelty: 0.05452547
p_int: 0.931617438
p_ni: 0.068382562
Score: 0.895
Data Source: BioPlex,STRINGDB
CCDC88C
Novelty: 0.0495648
p_int: 0.929212686
p_ni: 0.070787314
Score: 0.549
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (20)
Reactome (4)
KEGG (1)
PathwayCommons (2)
WikiPathways (13)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of folate and pterines | ||||
Reactome | Metabolism of vitamins and cofactors | ||||
Reactome | Metabolism of water-soluble vitamins and cofactors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of folate and pterines | ||||
Metabolism of vitamins and cofactors | ||||
Metabolism of water-soluble vitamins and cofactors | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (4)
Components (2)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
glycine measurement | 4 | 2 | 4 | 90.3 | |||||
urate measurement | 3 | 3 | 3 | 70.5 | |||||
glomerular filtration rate | 1 | 1 | 1 | 61.4 | |||||
serum metabolite measurement | 2 | 1 | 2 | 59.6 | |||||
homocysteine measurement | 1 | 1 | 1 | 56.4 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
glycine measurement | 4 | 90.3 | |||||
urate measurement | 3 | 70.5 | |||||
glomerular filtration rate | 1 | 61.4 | |||||
serum metabolite measurement | 2 | 59.6 | |||||
homocysteine measurement | 1 | 56.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | aldehyde dehydrogenase 1 family member L1 | 716977 | ||||||
Mouse | MGI:1340024 | 107747 | ||||||
Rat | RGD:621294 | 64392 | ||||||
Horse | aldehyde dehydrogenase 1 family member L1 | VGNC:15232 | 100061108 | |||||
Cow | aldehyde dehydrogenase 1 family member L1 | VGNC:25811 | 505677 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | aldehyde dehydrogenase 1 family member L1 | |||||
Mouse | ||||||
Rat | ||||||
Horse | aldehyde dehydrogenase 1 family member L1 | |||||
Cow | aldehyde dehydrogenase 1 family member L1 | |||||
Publication Statistics
PubMed Score 97.60
PubMed score by year
PubTator Score 98.65
PubTator score by year
Related Publications
Text Mined References (60)
GeneRif Annotations (22)
Items per page:
0 of 0
PMID | Year | Title |
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