ALDH1L1
Cytosolic 10-formyltetrahydrofolate dehydrogenase
Protein Summary
The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
- ENST00000273450
- ENSP00000273450
- ENSG00000144908
- ENST00000393431
- ENSP00000377081
- ENST00000393434
- ENSP00000377083
- ENST00000452905
- ENSP00000395881
- ENST00000455064
- ENSP00000414126
- ENST00000472186
- ENSP00000420293
- FTHFD
- FDH
- FTHFD
- 10-fTHF
- 10-FTHFDH
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
transcription factor perturbation | 0.88 | ||
kinase perturbation | 0.76 | ||
trait | 0.75 | ||
transcription factor | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 126.44 (req: < 5)
Gene RIFs: 25 (req: <= 3)
Antibodies: 412 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 126.44 (req: >= 5)
Gene RIFs: 25 (req: > 3)
Antibodies: 412 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0