Tbio TNFSF13 Tumor necrosis factor ligand superfamily member 13

Protein Summary

Description

Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

Uniprot Accession IDs

• O75888
• A8MYD5
• B4DVT2
• Q541E1
• Q5U0G8
• Q96HV6
• Q9P1M8
• Q9P1M9

Gene Name

• TNFSF13

Ensembl ID

• ENST00000338784
• ENSP00000343505
• ENSG00000161955
• ENST00000349228
• ENSP00000314455
• ENST00000396542
• ENSP00000379792
• ENST00000396545
• ENSP00000379794
• ENST00000625791
• ENSP00000486052

Symbol

• APRIL
• TALL2
• ZTNF2
• APRIL
• CD256
• TALL2
• ZTNF2
• TALL-2
• TNLG7B
• TRDL-1
• UNQ383/PRO715

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.91
PubMedID	0.79
cellular component	0.72
transcription factor	0.62
biological process	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.35   (req: < 5)

Gene RIFs: 187   (req: <= 3)

Antibodies: 714   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.35   (req: >= 5)

Gene RIFs: 187   (req: > 3)

Antibodies: 714   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0