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Tbio
TNFSF13
Tumor necrosis factor ligand superfamily member 13

Protein Summary
Description
Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338784
  • ENSP00000343505
  • ENSG00000161955
  • ENST00000349228
  • ENSP00000314455
  • ENST00000396542
  • ENSP00000379792
  • ENST00000396545
  • ENSP00000379794
  • ENST00000625791
  • ENSP00000486052

Symbol
  • APRIL
  • TALL2
  • ZTNF2
  • APRIL
  • CD256
  • TALL2
  • ZTNF2
  • TALL-2
  • TNLG7B
  • TRDL-1
  • UNQ383/PRO715
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.91
PubMedID
0.79
cellular component
0.72
transcription factor
0.62
biological process
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.32   (req: < 5)
Gene RIFs: 154   (req: <= 3)
Antibodies: 714   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.32   (req: >= 5)
Gene RIFs: 154   (req: > 3)
Antibodies: 714   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
2
1
2
92.2
1
1
0
1.4
78.7
alcohol consumption measurement
2
1
2
77.7
appendicular lean mass
1
1
1
66.9
albumin:globulin ratio measurement
1
1
1
64.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
2
92.2
0
1.4
78.7
alcohol consumption measurement
2
77.7
appendicular lean mass
1
66.9
albumin:globulin ratio measurement
1
64.5
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF superfamily member 13
VGNC:9728
100551504
Mouse
MGI:1916833
69583
Rat
RGD:1305871
287437
Cow
TNF superfamily member 13
538567
Opossum
tumor necrosis factor (ligand) superfamily, member 13
100551512
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF superfamily member 13
Mouse
Rat
Cow
TNF superfamily member 13
Opossum
tumor necrosis factor (ligand) superfamily, member 13
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75888-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
HuR (ELAVL1) binds and stabilizes mRNA
Reactome
Immune System
Reactome
Metabolism of RNA
Reactome
Regulation of mRNA stability by proteins that bind AU-rich elements
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
HuR (ELAVL1) binds and stabilizes mRNA
Immune System
Metabolism of RNA
Regulation of mRNA stability by proteins that bind AU-rich elements
Protein-Protein Interactions (28)
1 – 10 of 28
TNFRSF13B
Tbio
Novelty: 0.00338954
Score: 0.98
Data Source: Reactome,STRINGDB
TNFRSF17
Tbio
Novelty: 0.00222663
Score: 0.975
Data Source: Reactome,STRINGDB
TRAF5
Tbio
Novelty: 0.01238512
Score: 0.918
Data Source: STRINGDB
TRAF3
Tbio
Novelty: 0.0022525
Score: 0.916
Data Source: STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.91
Data Source: STRINGDB
TRAF2
Tbio
Novelty: 0.00983658
Score: 0.905
Data Source: STRINGDB
ELAVL1
Tchem
Novelty: 0.00110045
Score: 0.9
Data Source: STRINGDB
ANP32A
Tbio
Novelty: 0.00567095
Score: 0.9
Data Source: STRINGDB
SET
Tbio
Novelty: 0.01012327
Score: 0.9
Data Source: STRINGDB
NUP214
Tbio
Novelty: 0.00924336
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  35.32

PubMed score by year
PubTator Score  159.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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