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Tbio
STAM2
Signal transducing adapter molecule 2

Protein Summary
Description
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effec ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263904
  • ENSP00000263904
  • ENSG00000115145

Symbol
  • HBP
  • Hbp
  • STAM2A
  • STAM2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.86
virus perturbation
0.85
histone modification site profile
0.79
disease perturbation
0.74
protein domain
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.03   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 331   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.03   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (195)
UBC
Tbio
Novelty:  0.00204643
Score:  0.996
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.995
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.994
Data Source:  STRINGDB
HGS
Tbio
Family:  Enzyme
Novelty:  0.00665044
Score:  0.991
Data Source:  Reactome,STRINGDB
USP8
Tchem
Family:  Enzyme
Novelty:  0.0105645
Score:  0.982
Data Source:  Reactome,STRINGDB
TSG101
Tbio
Novelty:  0.00211746
Score:  0.982
Data Source:  Reactome,STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.977
Data Source:  STRINGDB
JAK3
Tclin
Family:  Kinase
Novelty:  0.00164278
Score:  0.974
Data Source:  STRINGDB
EPS15
Tchem
Novelty:  0.00451447
Score:  0.972
Data Source:  Reactome,STRINGDB
JAK1
Tclin
Family:  Kinase
Novelty:  0.00093625
Score:  0.971
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 4 of 4
TYK2
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
JAK1
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
JAK2
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
JAK3
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
Pathways (26)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

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Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Deubiquitination
Reactome
Disease
Reactome
EGFR downregulation
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Deubiquitination
Disease
EGFR downregulation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
LIFEdb
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
1
66.3
chemotherapy-induced alopecia
1
2
0
3
61.5
biological sex
1
1
1
47.6
1
1
0
19
29.3
sex hormone-binding globulin measurement
1
1
1
12.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
66.3
chemotherapy-induced alopecia
0
3
61.5
biological sex
1
47.6
0
19
29.3
sex hormone-binding globulin measurement
1
12.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
signal transducing adaptor molecule 2
VGNC:2868
459661
Macaque
signal transducing adaptor molecule 2
695286
Mouse
MGI:1929100
56324
Rat
RGD:1311497
311030
Dog
signal transducing adaptor molecule 2
VGNC:46876
476150
Species
Name
OMA
EggNOG
Inparanoid
Chimp
signal transducing adaptor molecule 2
Macaque
signal transducing adaptor molecule 2
Mouse
Rat
Dog
signal transducing adaptor molecule 2
Publication Statistics
PubMed Score 28.03
PubMed score by year
PubTator Score 14.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title